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Ibuprofen

Over-the-counter ANDA Official labelling
Informational index, not medical advice. Content is reproduced from public FDA and NLM data. Always confirm against the manufacturer's current prescribing information. Report adverse events to FDA MedWatch.

Overview

Brand name
ibuprofen
Generic name
Ibuprofen
Dosage form
Suspension/ Drops
Route
Oral
Marketing category
ANDA · ANDA
Labeler
Kroger Company
Product type
Human Otc Drug
DEA schedule
Not scheduled
Active ingredients
1
NDC product codes
5
Packages
6
Data completeness
82% of corroborating sources present

Active ingredients

Source: NDC Directory
Active ingredients and strengths as listed in the NDC Directory.
Ingredient Strength RxCUI Monograph
Ibuprofen 50 mg/1.25mL 310965 View

Forms, strengths and routes

Source: NDC Directory
Dosage form
Suspension/ Drops
Route of administration
Oral
Presentations
11

Pharmacologic classes are listed in the class section below.

Pharmacologic class

Source: NDC Directory
Established pharmacologic classes (EPC), mechanisms of action (MoA), chemical structures (CS) and physiologic effects (PE).
Class Type Browse
Anti-Inflammatory Agents EPC All 251 members
Cyclooxygenase Inhibitors [MoA] MoA All 251 members
Non-Steroidal [CS] CS All 251 members
Nonsteroidal Anti-inflammatory Drug [EPC] EPC All 251 members

Regulatory status

Source: Drugs@FDANDC Directory
Application number
075217
Application type
ANDA · Abbreviated New Drug Application
Approval date
December 16, 1998
Sponsor
L PERRIGO CO
Products on application
1
Submissions recorded
9
Products approved under application 075217.
Product Trade name Form Strength Ingredient Status TE Flags
075217-001 IBUPROFEN SUSPENSION/DROPS IBUPROFEN Over-the-counter —

Approval history

Source: Drugs@FDA
Most recent submissions on application 075217.
Type No. Action Status Date Review
Supplement 38 Labeling Approved May 24, 2011 —
Supplement 26 Labeling Approved March 22, 2006 —
Supplement 9 Labeling Approved May 22, 2003 —
Supplement 6 Manufacturing (CMC) Approved August 21, 2001 —
Supplement 5 Manufacturing (CMC) Approved June 14, 2001 —
Supplement 4 Labeling Approved October 18, 2000 —
Supplement 3 Labeling Approved May 24, 2000 —
Supplement 2 Manufacturing (CMC) Approved May 24, 2000 —
Original application 1 Approved December 16, 1998 —

Review documents

  • 0 · Original application · December 16, 1998
  • 0 · Original application · December 16, 1998
  • 0 · Original application · December 16, 1998

Prescribing information

Source: openFDA Drug Labeling

Reproduced verbatim from the Structured Product Labeling submitted to the FDA (effective 20260527). This is the manufacturer's labelling text, not a summary and not advice.

HUMAN OTC DRUG · 20260527 HUMAN OTC DRUG · 20250915

Indications and Usage

openFDA Drug Labeling

Uses temporarily: • reduces fever • relieves minor aches and pains due to the common cold, flu, sore throat, headaches and toothaches

Purposes Pain reliever/fever reducer

Dosage and Administration

openFDA Drug Labeling

Directions • this product does not contain directions or complete warnings for adult use • do not give more than directed • shake well before using • find right dose on chart below. If possible, use weight to dose; otherwise use age. • mL = milliliter • measure with the dosing device provided. Do not use with any other device. • dispense liquid slowly into the child’s mouth, toward the inner cheek • if needed, repeat dose every 6-8 hours • do not use more than 4 times a day Dosing Chart Weight (lbs) Age (mos) Dose (mL) under 6 mos ask a doctor 12-17 lbs 6-11 mos 1.25 mL 18-23 lbs 12-23 mos 1.875 mL

Warnings Allergy alert: Ibuprofen may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include: • hives • facial swelling • asthma (wheezing) • shock • skin reddening • rash • blisters If an allergic reaction occurs, stop use and seek medical help right away. Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if your child: • has had stomach ulcers or bleeding problems • takes a blood thinning (anticoagulant) or steroid drug • takes other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) • takes more or for a longer time than directed Heart attack and stroke warning : NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher if you use more than directed or for longer than directed. Sore throat warning: Severe or persistent sore throat or sore throat accompanied by high fever, headache, nausea, and vomiting may be serious. Consult doctor promptly. Do not use more than 2 days or administer to children under 3 years of age unless directed by doctor. Do not use • if the child has ever had an allergic reaction to ibuprofen or any other pain reliever/fever reducer • right before or after heart surgery Ask a doctor before use if • stomach bleeding warning applies to your child • child has a history of stomach problems, such as heartburn • child has problems or serious side effects from taking pain relievers or fever reducers • child has not been drinking fluids • child has lost a lot of fluid due to vomiting or diarrhea • child has high blood pressure, heart disease, liver cirrhosis, kidney disease, or had a stroke • child has asthma • child is taking a diuretic Ask a doctor or pharmacist before use if the child is • under a doctor’s care for any serious condition • taking any other drug When using this product • give with food or milk if stomach upset occurs Stop use and ask a doctor if • child experiences any of the following signs of stomach bleeding: • feels faint • vomits blood • has bloody or black stools • has stomach pain that does not get better • child has symptoms of heart problems or stroke: • chest pain • trouble breathing • weakness in one part or side of body • slurred speech • leg swelling • the child does not get any relief within first day (24 hours) of treatment • fever or pain gets worse or lasts more than 3 days • redness or swelling is present in the painful area • any new symptoms appear Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222)

Do not use • if the child has ever had an allergic reaction to ibuprofen or any other pain reliever/fever reducer • right before or after heart surgery

Ask a Doctor

openFDA Drug Labeling

Ask a doctor before use if • stomach bleeding warning applies to your child • child has a history of stomach problems, such as heartburn • child has problems or serious side effects from taking pain relievers or fever reducers • child has not been drinking fluids • child has lost a lot of fluid due to vomiting or diarrhea • child has high blood pressure, heart disease, liver cirrhosis, kidney disease, or had a stroke • child has asthma • child is taking a diuretic

Stop use and ask a doctor if • child experiences any of the following signs of stomach bleeding: • feels faint • vomits blood • has bloody or black stools • has stomach pain that does not get better • child has symptoms of heart problems or stroke: • chest pain • trouble breathing • weakness in one part or side of body • slurred speech • leg swelling • the child does not get any relief within first day (24 hours) of treatment • fever or pain gets worse or lasts more than 3 days • redness or swelling is present in the painful area • any new symptoms appear

Active Ingredient

openFDA Drug Labeling

Active ingredient (in each 1.25 mL) Ibuprofen 50 mg (NSAID)* *nonsteroidal anti-inflammatory drug

Adverse event reports

Source: openFDA FAERS
283,546
FAERS reports mentioning this drug
as of 2026-09-25T03:42:24+00:00
A report count is not a risk measure. FAERS accepts voluntary and mandatory reports without establishing causation, and reporting is influenced by how widely a drug is used, how long it has been marketed, and media attention. FDA states that reports “do not prove that the drug caused the event”. Compare rates, not totals.

Attributed to this product's most-reported active ingredient: IBUPROFEN. Combination products with more than six active ingredients are not attributed, because a report count summed across a long ingredient list measures the list, not the medicine.

Packaging and NDCs

Source: NDC Directory
Every National Drug Code package associated with this medication. The NDC is the identifier used for dispensing, billing and pharmacovigilance in the United States.
Package NDC Product NDC Labeler Description Marketing start
59779-313-10 59779-313 CVS Pharmacy 1 BOTTLE in 1 CARTON (59779-313-10) / 30 mL in 1 BOTTLE May 7, 2004
30142-255-10 30142-255 Kroger Company 1 BOTTLE in 1 CARTON (30142-255-10) / 30 mL in 1 BOTTLE May 15, 2010
41250-255-10 41250-255 Meijer Distribution Inc 1 BOTTLE in 1 CARTON (41250-255-10) / 30 mL in 1 BOTTLE April 18, 2004
11822-0255-1 11822-0255 Rite Aid Corporation 1 BOTTLE in 1 CARTON (11822-0255-1) / 30 mL in 1 BOTTLE June 3, 2005
51672-2146-3 51672-2146 Sun Pharmaceutical Industries, Inc. 1 BOTTLE in 1 CARTON (51672-2146-3) / 30 mL in 1 BOTTLE August 8, 2023
51672-2146-5 51672-2146 Sun Pharmaceutical Industries, Inc. 1 BOTTLE in 1 CARTON (51672-2146-5) / 15 mL in 1 BOTTLE December 3, 2024
59779-313 59779-313 CVS Pharmacy — May 7, 2004
30142-255 30142-255 Kroger Company — May 15, 2010
41250-255 41250-255 Meijer Distribution Inc — April 18, 2004
11822-0255 11822-0255 Rite Aid Corporation — June 3, 2005
51672-2146 51672-2146 Sun Pharmaceutical Industries, Inc. — August 8, 2023

Sources for this page

Every dataset that contributed a fact to this page.
Dataset Agency Used for
NDC Directory FDA Identity, ingredients, strengths, forms, routes, labelers, packages
Drugs@FDA FDA Application, sponsor, submissions, review documents, marketing status
Drug Labeling FDA / NLM Prescribing information reproduced above
FAERS FDA Adverse event report counts

Generated September 25, 2026 · 11 sections on this page.