EAZI-BREEDTM CIDR® Cattle Insert — veterinary medication

Overview

Source: Animal Drugs @ FDA

Proprietary name

EAZI-BREEDTM CIDR® Cattle Insert

Active ingredient

Progesterone

Application type

NADA

Sponsor

Zoetis Inc.

Applications on record

1

First published

March 2, 2021

Adverse event reports

Source: openFDA VeDDRA

841

Reports mentioning this ingredient

October 12, 2002 – March 11, 2026

75

Classified serious

per reporter assessment

182

Lack of expected efficacy

resistance signal

21

Human operator exposure

needle-stick or splash

Not a risk measure. Veterinary adverse event reports are influenced by how many animals are treated, reporting practice and product age. Reports do not establish that the product caused the event, and a single report can cover an entire herd or flock. Attribution here is by active ingredient because the source dataset redacts brand names.

Attributed by active ingredient “PROGESTERONE”. Green Book ingredient names and VeDDRA ingredient names do not always agree exactly, so attribution is approximate and labelled as such.

Reported reactions

Source: openFDA VeDDRA

Clinical signs coded in the VICH VeDDRA four-level hierarchy, most frequent first.

Reaction terms reported for this ingredient, by report count.
Reaction (VeDDRA term)	Reports	Relative frequency
INEFFECTIVE, ESTRUS SYNCHRONIZ	211
Insert, Damaged	62
Lack of efficacy - NOS	58
Product Defect, General	53
Containers, Damaged	49
Insert, Abnormal	36
Underfilling, Package	35
Implant, Abnormal	34
No sign	32
Rectal prolapse	32
Vaginitis	29
Death	28
Device Defective NOS	27
Uncoded sign	27
Unclassifiable adverse event	24
Tablets, Abnormal	24
Color, Abnormal	22
Accidental exposure	20
INEFFECTIVE, ESTRUS INDUCTION	18
Applicator, Abnormal	17

Species affected

Source: openFDA VeDDRA

Cattle 482 Sheep 28 Human 22 Goat 18 Dog 7 Horse 5 Other Deer 2 White tailed deer 2 Other 1

Regulatory context

New Animal Drug Application (NADA). A pioneer approval evaluated for target animal safety, therapeutic effectiveness, manufacturing controls and — for food-producing species — human food safety including residue depletion.

Extra-label use in food-producing animals is governed by the Animal Medicinal Drug Use Clarification Act of 1994 (AMDUCA) and 21 CFR Part 530. It requires a valid veterinarian-client-patient relationship and is prohibited outright for certain drug classes. Withdrawal times are determined by FARAD, not by this index.

Sources for this page

Animal Drugs @ FDA	FDA CVM	Applications, sponsor, status, withdrawal
Animal & Veterinary Events	FDA CVM	VeDDRA adverse event aggregates by active ingredient