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Signature Care Ibuprofen

Ibuprofen · Tablet, Film Coated

Over-the-counter ANDA Official labelling
Informational index, not medical advice. Content is reproduced from public FDA and NLM data. Always confirm against the manufacturer's current prescribing information. Report adverse events to FDA MedWatch.

Overview

Brand name
Signature Care Ibuprofen
Generic name
Ibuprofen
Dosage form
Tablet, Film Coated
Route
Oral
Marketing category
ANDA · ANDA
Labeler
Safeway
Product type
Human Otc Drug
DEA schedule
Not scheduled
Active ingredients
1
NDC product codes
2
Packages
5
Data completeness
76% of corroborating sources present

Active ingredients

Source: NDC Directory
Active ingredients and strengths as listed in the NDC Directory.
Ingredient Strength RxCUI Monograph
Ibuprofen 200 mg/1 310965 View

Forms, strengths and routes

Source: NDC Directory
Dosage form
Tablet, Film Coated
Route of administration
Oral
Presentations
7

Pharmacologic classes are listed in the class section below.

Pharmacologic class

Source: NDC Directory
Established pharmacologic classes (EPC), mechanisms of action (MoA), chemical structures (CS) and physiologic effects (PE).
Class Type Browse
Anti-Inflammatory Agents EPC All 251 members
Cyclooxygenase Inhibitors [MoA] MoA All 251 members
Non-Steroidal [CS] CS All 251 members
Nonsteroidal Anti-inflammatory Drug [EPC] EPC All 251 members

Regulatory status

Source: Drugs@FDANDC Directory
Application number
072096
Application type
ANDA · Abbreviated New Drug Application
Approval date
December 8, 1987
Sponsor
PERRIGO
Products on application
1
Submissions recorded
44
Products approved under application 072096.
Product Trade name Form Strength Ingredient Status TE Flags
072096-001 IBUPROFEN TABLET IBUPROFEN Over-the-counter —

Approval history

Source: Drugs@FDA
Most recent submissions on application 072096.
Type No. Action Status Date Review
Supplement 115 Labeling Approved May 11, 2023 Standard
Supplement 111 Manufacturing (CMC) Approved May 11, 2023 —
Supplement 103 Labeling Approved May 11, 2023 Standard
Supplement 99 Labeling Approved July 13, 2016 —
Supplement 97 Manufacturing (CMC) Approved June 23, 2016 Unknown
Supplement 76 Labeling Approved November 26, 2012 —
Supplement 72 Labeling Approved January 25, 2010 —
Supplement 70 Labeling Approved January 16, 2008 —
Supplement 63 Labeling Approved March 22, 2006 —
Supplement 33 Labeling Approved February 20, 2004 —
Supplement 44 Labeling Approved March 28, 2003 —
Supplement 42 Manufacturing (CMC) Approved November 26, 2002 —
Supplement 41 Manufacturing (CMC) Approved November 26, 2002 —
Supplement 40 Manufacturing (CMC) Approved November 26, 2002 —
Supplement 37 Labeling Approved September 12, 2001 —
Supplement 36 Manufacturing (CMC) Approved August 21, 2001 —
Supplement 35 Manufacturing (CMC) Approved August 21, 2001 —
Supplement 32 Manufacturing (CMC) Approved June 19, 2001 —
Supplement 34 Labeling Approved October 26, 2000 —
Supplement 31 Manufacturing (CMC) Approved March 27, 2000 —
Supplement 30 Manufacturing (CMC) Approved October 1, 1999 —
Supplement 25 Manufacturing (CMC) Approved June 23, 1999 —
Supplement 24 Manufacturing (CMC) Approved June 23, 1999 —
Supplement 29 Labeling Approved March 11, 1999 —
Supplement 22 Manufacturing (CMC) Approved July 25, 1997 —
Supplement 21 Manufacturing (CMC) Approved July 25, 1997 —
Supplement 19 Manufacturing (CMC) Approved July 22, 1996 —
Supplement 23 Labeling Approved July 15, 1996 —
Supplement 16 Labeling Approved July 15, 1996 —
Supplement 20 Manufacturing (CMC) Approved March 22, 1996 —
Supplement 17 Manufacturing (CMC) Approved June 1, 1995 —
Supplement 15 Manufacturing (CMC) Approved April 6, 1995 —
Supplement 14 Manufacturing (CMC) Approved February 13, 1995 —
Supplement 13 Manufacturing (CMC) Approved July 11, 1994 —
Supplement 12 Manufacturing (CMC) Approved July 6, 1994 —
Supplement 11 Labeling Approved January 11, 1994 —
Supplement 10 Manufacturing (CMC) Approved January 11, 1994 —
Supplement 9 Manufacturing (CMC) Approved November 15, 1993 —
Supplement 5 Manufacturing (CMC) Approved February 11, 1993 —
Supplement 7 Manufacturing (CMC) Approved November 30, 1992 —
Supplement 6 Manufacturing (CMC) Approved November 30, 1992 —
Supplement 8 Manufacturing (CMC) Approved July 3, 1991 —
Supplement 1 Manufacturing (CMC) Approved March 28, 1989 —
Original application 1 Approved December 8, 1987 —

Prescribing information

Source: openFDA Drug Labeling

Reproduced verbatim from the Structured Product Labeling submitted to the FDA (effective 20240201). This is the manufacturer's labelling text, not a summary and not advice.

HUMAN OTC DRUG · 20240201 HUMAN OTC DRUG · 20230928

Indications and Usage

openFDA Drug Labeling

Uses • temporarily relieves minor aches and pains due to: • headache • muscular aches • minor pain of arthritis • toothache • backache • the common cold • menstrual cramps • temporarily reduces fever

Purposes Pain reliever/fever reducer

Dosage and Administration

openFDA Drug Labeling

Directions • do not take more than directed • the smallest effective dose should be used adults and children 12 years and older • take 1 caplet every 4 to 6 hours while symptoms persist • if pain or fever does not respond to 1 caplet, 2 caplets may be used • do not exceed 6 caplets in 24 hours, unless directed by a doctor children under 12 years • ask a doctor

Warnings Allergy alert: Ibuprofen may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include: • hives • facial swelling • asthma (wheezing) • shock • skin reddening • rash • blisters If an allergic reaction occurs, stop use and seek medical help right away. Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you • are age 60 or older • have had stomach ulcers or bleeding problems • take a blood thinning (anticoagulant) or steroid drug • take other drugs containing prescription or nonprescription NSAIDs [aspirin, ibuprofen, naproxen, or others] • have 3 or more alcoholic drinks every day while using this product • take more or for a longer time than directed Heart attack and stroke warning: NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher if you use more than directed or for longer than directed. Do not use • if you have ever had an allergic reaction to ibuprofen or any other pain reliever/fever reducer • right before or after heart surgery Ask a doctor before use if • you have problems or serious side effects from taking pain relievers or fever reducers • the stomach bleeding warning applies to you • you have a history of stomach problems, such as heartburn • you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, or had a stroke • you are taking a diuretic Ask a doctor or pharmacist before use if you are • taking aspirin for heart attack or stroke, because ibuprofen may decrease this benefit of aspirin • under a doctor’s care for any serious condition • taking any other drug When using this product • take with food or milk if stomach upset occurs Stop use and ask a doctor if • you experience any of the following signs of stomach bleeding: • feel faint • vomit blood • have bloody or black stools • have stomach pain that does not get better • you have symptoms of heart problems or stroke: • chest pain • trouble breathing • weakness in one part or side of body • slurred speech • leg swelling • pain gets worse or lasts more than 10 days • fever gets worse or lasts more than 3 days • redness or swelling is present in the painful area • any new symptoms appear If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use ibuprofen during at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222).

Do not use • if you have ever had an allergic reaction to ibuprofen or any other pain reliever/fever reducer • right before or after heart surgery

Ask a Doctor

openFDA Drug Labeling

Ask a doctor before use if • you have problems or serious side effects from taking pain relievers or fever reducers • the stomach bleeding warning applies to you • you have a history of stomach problems, such as heartburn • you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, or had a stroke • you are taking a diuretic

Stop use and ask a doctor if • you experience any of the following signs of stomach bleeding: • feel faint • vomit blood • have bloody or black stools • have stomach pain that does not get better • you have symptoms of heart problems or stroke: • chest pain • trouble breathing • weakness in one part or side of body • slurred speech • leg swelling • pain gets worse or lasts more than 10 days • fever gets worse or lasts more than 3 days • redness or swelling is present in the painful area • any new symptoms appear

Active Ingredient

openFDA Drug Labeling

Active ingredient (in each caplet) Ibuprofen 200 mg (NSAID)* *nonsteroidal anti-inflammatory drug

Adverse event reports

Source: openFDA FAERS
283,546
FAERS reports mentioning this drug
as of 2026-09-25T03:42:24+00:00
A report count is not a risk measure. FAERS accepts voluntary and mandatory reports without establishing causation, and reporting is influenced by how widely a drug is used, how long it has been marketed, and media attention. FDA states that reports “do not prove that the drug caused the event”. Compare rates, not totals.

Attributed to this product's most-reported active ingredient: IBUPROFEN. Combination products with more than six active ingredients are not attributed, because a report count summed across a long ingredient list measures the list, not the medicine.

Packaging and NDCs

Source: NDC Directory
Every National Drug Code package associated with this medication. The NDC is the identifier used for dispensing, billing and pharmacovigilance in the United States.
Package NDC Product NDC Labeler Description Marketing start
21130-818-62 21130-818 Safeway 1 BOTTLE in 1 CARTON (21130-818-62) / 24 TABLET, FILM COATED in 1 BOTTLE September 14, 2015
21130-818-71 21130-818 Safeway 1 BOTTLE in 1 CARTON (21130-818-71) / 50 TABLET, FILM COATED in 1 BOTTLE September 28, 2015
21130-818-78 21130-818 Safeway 1 BOTTLE in 1 CARTON (21130-818-78) / 100 TABLET, FILM COATED in 1 BOTTLE September 24, 2015
21130-818-90 21130-818 Safeway 500 TABLET, FILM COATED in 1 BOTTLE (21130-818-90) September 28, 2015
21130-877-78 21130-877 Safeway 1 BOTTLE in 1 CARTON (21130-877-78) / 100 TABLET, FILM COATED in 1 BOTTLE September 14, 2015
21130-818 21130-818 Safeway — September 14, 2015
21130-877 21130-877 Safeway — September 14, 2015

Sources for this page

Every dataset that contributed a fact to this page.
Dataset Agency Used for
NDC Directory FDA Identity, ingredients, strengths, forms, routes, labelers, packages
Drugs@FDA FDA Application, sponsor, submissions, review documents, marketing status
Drug Labeling FDA / NLM Prescribing information reproduced above
FAERS FDA Adverse event report counts

Generated September 25, 2026 · 10 sections on this page.