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Motrin IB

Ibuprofen · Tablet, Film Coated

Over-the-counter ANDA Official labelling
Informational index, not medical advice. Content is reproduced from public FDA and NLM data. Always confirm against the manufacturer's current prescribing information. Report adverse events to FDA MedWatch.

Overview

Brand name
Motrin IB
Generic name
Ibuprofen
Dosage form
Tablet, Film Coated
Route
Oral
Marketing category
ANDA · ANDA
Labeler
Jones Healthcare Group - Packaging Services, Inc
Product type
Human Otc Drug
DEA schedule
Not scheduled
Active ingredients
1
NDC product codes
8
Packages
26
Data completeness
82% of corroborating sources present

Active ingredients

Source: NDC Directory
Active ingredients and strengths as listed in the NDC Directory.
Ingredient Strength RxCUI Monograph
Ibuprofen 200 mg/1 310965 View

Forms, strengths and routes

Source: NDC Directory
Dosage form
Tablet, Film Coated
Route of administration
Oral
Presentations
34

Pharmacologic classes are listed in the class section below.

Pharmacologic class

Source: NDC Directory
Established pharmacologic classes (EPC), mechanisms of action (MoA), chemical structures (CS) and physiologic effects (PE).
Class Type Browse
Anti-Inflammatory Agents EPC All 251 members
Cyclooxygenase Inhibitors [MoA] MoA All 251 members
Non-Steroidal [CS] CS All 251 members
Nonsteroidal Anti-inflammatory Drug [EPC] EPC All 251 members

Regulatory status

Source: Drugs@FDANDC Directory
Application number
077349
Application type
ANDA · Abbreviated New Drug Application
Approval date
June 21, 2005
Sponsor
PERRIGO R AND D
Products on application
1
Submissions recorded
7
Products approved under application 077349.
Product Trade name Form Strength Ingredient Status TE Flags
077349-001 IBUPROFEN TABLET IBUPROFEN Over-the-counter — RS

Therapeutic equivalence

Source: Orange Book
TE code
—
Reference Listed Drug
No
Reference Standard
Yes

Codes beginning with “A” indicate products the FDA considers therapeutically equivalent. Codes beginning with “B” indicate bioequivalence has not been established. See methodology.

Approval history

Source: Drugs@FDA
Most recent submissions on application 077349.
Type No. Action Status Date Review
Supplement 43 Labeling Approved November 15, 2022 Standard
Supplement 34 Labeling Approved November 15, 2022 Standard
Supplement 32 Labeling Approved November 15, 2022 Standard
Supplement 14 Labeling Approved September 21, 2012 —
Supplement 8 Labeling Approved January 16, 2008 —
Supplement 1 Labeling Approved March 22, 2006 —
Original application 1 Approved June 21, 2005 —

Prescribing information

Source: openFDA Drug Labeling

Reproduced verbatim from the Structured Product Labeling submitted to the FDA (effective 20260101). This is the manufacturer's labelling text, not a summary and not advice.

HUMAN OTC DRUG · 20260101 HUMAN OTC DRUG · 20251117 HUMAN OTC DRUG · 20230316

Indications and Usage

openFDA Drug Labeling

Uses ■ temporarily relieves minor aches and pains due to: ■ headache ■ muscular aches ■ minor pain of arthritis ■ toothache ■ backache ■ the common cold ■ menstrual cramps ■ temporarily reduces fever

Purposes Pain reliever/fever reducer

Dosage and Administration

openFDA Drug Labeling

Directions ■ do not take more than directed ■ the smallest effective dose should be used adults and children 12 years and older ■ take 1 caplet every 4 to 6 hours while symptoms persist ■ if pain or fever does not respond to 1 caplet, 2 caplets may be used ■ do not exceed 6 caplets in 24 hours, unless directed by a doctor children under 12 years ■ ask a doctor

Warnings Allergy Alert: Ibuprofen may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include: • hives • facial swelling • asthma (wheezing) • shock • skin reddening • rash • blisters If an allergic reaction occurs, stop use and seek medical help right away. Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you: • are age 60 or older • have had stomach ulcers or bleeding problems • take a blood thinning (anticoagulant) or steroid drug • take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) • have 3 or more alcoholic drinks every day while using this product • take more or for a longer time than directed Heart attack and stroke warning: NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher if you use more than directed or for longer than directed. Do not use • if you have ever had an allergic reaction to any other pain reliever/fever reducer • right before or after heart surgery Ask a doctor before use if • you have problems or serious side effects from taking pain relievers or fever reducers • the stomach bleeding warning applies to you • you have a history of stomach problems, such as heartburn • you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, or had a stroke • you are taking a diuretic Ask a doctor or pharmacist before use if you are • taking aspirin for heart attack or stroke, because ibuprofen may decrease this benefit of aspirin • under a doctor’s care for any serious condition • taking any other drug When using this product • take with food or milk if stomach upset occurs Stop use and ask a doctor if • you experience any of the following signs of stomach bleeding: • feel faint • vomit blood • have bloody or black stools • have stomach pain that does not get better • you have symptoms of heart problems or stroke: • chest pain • trouble breathing • weakness in one part or side of body • slurred speech • leg swelling • pain gets worse or lasts more than 10 days • fever gets worse or lasts more than 3 days • redness or swelling is present in the painful area • any new symptoms appear If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use ibuprofen during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222).

Do not use if you have ever had an allergic reaction to ibuprofen or any other pain reliever/fever reducer right before or after heart surgery

Ask a Doctor

openFDA Drug Labeling

Ask a doctor before use if • you have problems or serious side effects from taking pain relievers or fever reducers • the stomach bleeding warning applies to you • you have a history of stomach problems, such as heartburn • you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, or had a stroke • you are taking a diuretic

Stop use and ask a doctor if ■ you experience any of the following signs of stomach bleeding: ■ feel faint ■ vomit blood ■have bloody or black stools ■ have stomach pain that does not get better ■ you have symptoms of heart problems or stroke: ■ chest pain ■ trouble breathing ■ weakness in one part or side of the body ■ slurred speech ■ leg swelling ■ pain gets worse or lasts more than 10 days ■ fever gets worse or lasts more than 3 days ■ redness or swelling is present in the painful area ■ any new symptoms appear

Active Ingredient

openFDA Drug Labeling

Active ingredient (in each caplet) Ibuprofen 200 mg (NSAID)* *nonsteroidal anti-inflammatory drug Purpose Pain reliever/fever reducer

Adverse event reports

Source: openFDA FAERS
283,546
FAERS reports mentioning this drug
as of 2026-09-25T03:42:24+00:00
A report count is not a risk measure. FAERS accepts voluntary and mandatory reports without establishing causation, and reporting is influenced by how widely a drug is used, how long it has been marketed, and media attention. FDA states that reports “do not prove that the drug caused the event”. Compare rates, not totals.

Attributed to this product's most-reported active ingredient: IBUPROFEN. Combination products with more than six active ingredients are not attributed, because a report count summed across a long ingredient list measures the list, not the medicine.

Packaging and NDCs

Source: NDC Directory
Every National Drug Code package associated with this medication. The NDC is the identifier used for dispensing, billing and pharmacovigilance in the United States.
Package NDC Product NDC Labeler Description Marketing start
67414-240-00 67414-240 Jones Healthcare Group - Packaging Services, Inc 2500 POUCH in 1 BOX (67414-240-00) / 2 TABLET, FILM COATED in 1 POUCH January 25, 2018
67414-240-09 67414-240 Jones Healthcare Group - Packaging Services, Inc 50 POUCH in 1 CARTON (67414-240-09) / 2 TABLET, FILM COATED in 1 POUCH January 25, 2018
50580-230-01 50580-230 Kenvue Brands LLC 1 BOTTLE in 1 CARTON (50580-230-01) / 50 TABLET, FILM COATED in 1 BOTTLE July 1, 2016
50580-230-02 50580-230 Kenvue Brands LLC 1 BOTTLE in 1 CARTON (50580-230-02) / 60 TABLET, FILM COATED in 1 BOTTLE July 1, 2016
50580-230-03 50580-230 Kenvue Brands LLC 1 BOTTLE in 1 CARTON (50580-230-03) / 100 TABLET, FILM COATED in 1 BOTTLE July 1, 2016
50580-230-04 50580-230 Kenvue Brands LLC 1 BOTTLE in 1 CARTON (50580-230-04) / 225 TABLET, FILM COATED in 1 BOTTLE July 1, 2016
50580-230-05 50580-230 Kenvue Brands LLC 1 BOTTLE in 1 CARTON (50580-230-05) / 300 TABLET, FILM COATED in 1 BOTTLE July 1, 2016
50580-230-06 50580-230 Kenvue Brands LLC 1 BOTTLE in 1 CARTON (50580-230-06) / 500 TABLET, FILM COATED in 1 BOTTLE July 1, 2016
50580-230-07 50580-230 Kenvue Brands LLC 1 BOTTLE in 1 CARTON (50580-230-07) / 24 TABLET, FILM COATED in 1 BOTTLE July 17, 2017
50580-230-08 50580-230 Kenvue Brands LLC 2 TABLET, FILM COATED in 1 POUCH (50580-230-08) June 30, 2017
50580-230-09 50580-230 Kenvue Brands LLC 50 POUCH in 1 CARTON (50580-230-09) / 2 TABLET, FILM COATED in 1 POUCH April 24, 2017
66715-9812-2 66715-9812 Lil' Drug Store Products, Inc. 2 POUCH in 1 CARTON (66715-9812-2) / 2 TABLET, FILM COATED in 1 POUCH June 18, 2018
66715-9812-3 66715-9812 Lil' Drug Store Products, Inc. 3 POUCH in 1 CARTON (66715-9812-3) / 2 TABLET, FILM COATED in 1 POUCH August 15, 2019
66715-9812-8 66715-9812 Lil' Drug Store Products, Inc. 30 POUCH in 1 BOX, UNIT-DOSE (66715-9812-8) / 2 TABLET, FILM COATED in 1 POUCH April 19, 2022
53209-2001-2 53209-2001 Morning Star OTC 25 BLISTER PACK in 1 POUCH (53209-2001-2) / 2 TABLET, FILM COATED in 1 BLISTER PACK (53209-2001-1) June 19, 2025
67751-120-01 67751-120 Navajo Manufacturing Company Inc. 1 POUCH in 1 CARTON (67751-120-01) / 2 TABLET, FILM COATED in 1 POUCH September 22, 2016
67751-120-02 67751-120 Navajo Manufacturing Company Inc. 2 POUCH in 1 CARTON (67751-120-02) / 2 TABLET, FILM COATED in 1 POUCH September 22, 2016
70264-029-01 70264-029 R J General Corporation 50 POUCH in 1 BOX (70264-029-01) / 2 TABLET, FILM COATED in 1 POUCH May 1, 2021
73097-028-02 73097-028 Savings Distributors LLC 1 POUCH in 1 CARTON (73097-028-02) / 2 TABLET, FILM COATED in 1 POUCH January 1, 2026
73097-028-40 73097-028 Savings Distributors LLC 20 POUCH in 1 CARTON (73097-028-40) / 2 TABLET, FILM COATED in 1 POUCH January 1, 2026
73097-028-50 73097-028 Savings Distributors LLC 25 POUCH in 1 CARTON (73097-028-50) / 2 TABLET, FILM COATED in 1 POUCH January 1, 2026
85237-1947-1 85237-1947 Select Consumer Group LLC 1 POUCH in 1 CONTAINER (85237-1947-1) / 2 TABLET, FILM COATED in 1 POUCH (85237-1947-0) June 4, 2025
85237-1947-2 85237-1947 Select Consumer Group LLC 2 POUCH in 1 CONTAINER (85237-1947-2) / 2 TABLET, FILM COATED in 1 POUCH (85237-1947-0) June 4, 2025
85237-1947-4 85237-1947 Select Consumer Group LLC 25 POUCH in 1 CARTON (85237-1947-4) / 2 TABLET, FILM COATED in 1 POUCH (85237-1947-0) June 4, 2025
85237-1947-5 85237-1947 Select Consumer Group LLC 30 POUCH in 1 CARTON (85237-1947-5) / 2 TABLET, FILM COATED in 1 POUCH (85237-1947-0) June 4, 2025
85237-1947-7 85237-1947 Select Consumer Group LLC 3 POUCH in 1 CONTAINER (85237-1947-7) / 2 TABLET, FILM COATED in 1 POUCH (85237-1947-0) June 4, 2025
67414-240 67414-240 Jones Healthcare Group - Packaging Services, Inc — July 1, 2016
50580-230 50580-230 Kenvue Brands LLC — July 1, 2016
66715-9812 66715-9812 Lil' Drug Store Products, Inc. — January 3, 2012
53209-2001 53209-2001 Morning Star OTC — June 19, 2025
67751-120 67751-120 Navajo Manufacturing Company Inc. — September 22, 2016
70264-029 70264-029 R J General Corporation — May 1, 2021
73097-028 73097-028 Savings Distributors LLC — January 1, 2026
85237-1947 85237-1947 Select Consumer Group LLC — July 1, 2016

Sources for this page

Every dataset that contributed a fact to this page.
Dataset Agency Used for
NDC Directory FDA Identity, ingredients, strengths, forms, routes, labelers, packages
Drugs@FDA FDA Application, sponsor, submissions, review documents, marketing status
Drug Labeling FDA / NLM Prescribing information reproduced above
FAERS FDA Adverse event report counts

Generated September 25, 2026 · 11 sections on this page.