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Ibuprofen PM
IBUPROFEN, Diphenhydramine Hcl · Capsule, Liquid Filled
Overview
Active ingredients
Source: NDC DirectoryForms, strengths and routes
Source: NDC DirectoryPharmacologic classes are listed in the class section below.
Pharmacologic class
Source: NDC Directory| Class | Type | Browse |
|---|---|---|
| Anti-Inflammatory Agents | EPC | All 251 members |
| Cyclooxygenase Inhibitors [MoA] | MoA | All 251 members |
| Histamine H1 Receptor Antagonists [MoA] | MoA | All 136 members |
| Histamine-1 Receptor Antagonist [EPC] | EPC | All 134 members |
| Non-Steroidal [CS] | CS | All 251 members |
| Nonsteroidal Anti-inflammatory Drug [EPC] | EPC | All 251 members |
Regulatory status
Source: Drugs@FDANDC Directory| Product | Trade name | Form | Strength | Ingredient | Status | TE | Flags |
|---|---|---|---|---|---|---|---|
| 090397-001 | IBUPROFEN AND DIPHENHYDRAMINE HYDROCHLORIDE | CAPSULE | DIPHENHYDRAMINE HYDROCHLORIDE; IBUPROFEN | Over-the-counter | — |
Approval history
Source: Drugs@FDA| Type | No. | Action | Status | Date | Review |
|---|---|---|---|---|---|
| Original application | 1 | Approved | November 22, 2010 | — |
Prescribing information
Source: openFDA Drug LabelingReproduced verbatim from the Structured Product Labeling submitted to the FDA (effective 20260417). This is the manufacturer's labelling text, not a summary and not advice.
Indications and Usage
openFDA Drug LabelingUses ■ for relief of occasional sleeplessness when associated with minor aches and pains ■ helps you fall asleep and stay asleep
Purpose
openFDA Drug LabelingPurposes Nighttime sleep-aid Pain reliever
Dosage and Administration
openFDA Drug LabelingDirections ■ do not take more than directed ■ adults and children 12 years and over: take 2 capsules at bedtime ■ do not take more than 2 capsules in 24 hours
Warnings
openFDA Drug LabelingWarnings Allergy alert: Ibuprofen may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include: ■ hives ■ facial swelling ■ asthma (wheezing) ■ shock ■ skin reddening ■ rash ■ blisters. If an allergic reaction occurs, stop use and seek medical help right away. Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you ■ are age 60 or older ■ have had stomach ulcers or bleeding problems ■ take a blood thinning (anticoagulant) or steroid drug ■ take other drugs containing prescription or nonprescription NSAIDs [aspirin, ibuprofen, naproxen, or others] ■ have 3 or more alcoholic drinks every day while using this product ■ take more or for a longer time than directed Heart attack and stroke warning: NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher if you use more than directed or for longer than directed. Do not use ■ if you have ever had an allergic reaction to any other pain reliever/fever reducer ■ unless you have time for a full night’s sleep ■ in children under 12 years of age ■ right before or after heart surgery ■ with any other product containing diphenhydramine, even one used on skin ■ if you have sleeplessness without pain Ask a doctor before use if ■ stomach bleeding warning applies to you ■ you have problems or serious side effects from taking pain relievers or fever reducers ■ you have a history of stomach problems, such as heartburn ■ you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, or had a stroke ■ you are taking a diuretic ■ you have a breathing problem such as emphysema or chronic bronchitis ■ you have glaucoma ■ you have trouble urinating due to an enlarged prostate gland Ask a doctor or pharmacist before use if you are ■ taking sedatives or tranquilizers, or any other sleep-aid ■ under a doctor's care for any continuing medical illness ■ taking any other antihistamines ■ taking aspirin for heart attack or stroke, because ibuprofen may decrease this benefit of aspirin ■ taking any other drug When using this product ■ drowsiness will occur ■ avoid alcoholic drinks ■ do not drive a motor vehicle or operate machinery ■ take with food or milk if stomach upset occurs Stop use and ask a doctor if ■ you experience any of the following signs of stomach bleeding: ■ feel faint ■ vomit blood ■ have bloody or black stools ■ have stomach pain that does not get better ■ you have symptoms of heart problems or stroke: ■ chest pain ■ trouble breathing ■ weakness in one part or side of body ■ slurred speech ■ leg swelling ■ pain gets worse or lasts more than 10 days ■ sleeplessness persists continuously for more than 2 weeks. Insomnia may be a symptom of a serious underlying medical illness ■ redness or swelling is present in the painful area ■ any new symptoms appear If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use ibuprofen at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause delivery problems in the unborn child or complications during delivery. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.
Do Not Use
openFDA Drug LabelingDo not use ■ if you have ever had an allergic reaction to any other pain reliever/fever reducer ■ unless you have time for a full night’s sleep ■ in children under 12 years of age ■ right before or after heart surgery ■ with any other product containing diphenhydramine, even one used on skin ■ if you have sleeplessness without pain
Ask a Doctor
openFDA Drug LabelingAsk a doctor before use if ■ stomach bleeding warning applies to you ■ you have problems or serious side effects from taking pain relievers or fever reducers ■ you have a history of stomach problems, such as heartburn ■ you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, or had a stroke ■ you are taking a diuretic ■ you have a breathing problem such as emphysema or chronic bronchitis ■ you have glaucoma ■ you have trouble urinating due to an enlarged prostate gland
Stop Use
openFDA Drug LabelingStop use and ask a doctor if ■ you experience any of the following signs of stomach bleeding: ■ feel faint ■ vomit blood ■ have bloody or black stools ■ have stomach pain that does not get better ■ you have symptoms of heart problems or stroke: ■ chest pain ■ trouble breathing ■ weakness in one part or side of body ■ slurred speech ■ leg swelling ■ pain gets worse or lasts more than 10 days ■ sleeplessness persists continuously for more than 2 weeks. Insomnia may be a symptom of a serious underlying medical illness. ■ redness or swelling is present in the painful area ■ any new symptoms appear
Active Ingredient
openFDA Drug LabelingActive ingredient (in each capsule) Diphenhydramine hydrochloride USP 25 mg Solubilized ibuprofen equal to 200 mg ibuprofen (NSAID)* (present as the free acid and potassium salt) *non-steroidal anti-inflammatory drug
Adverse event reports
Source: openFDA FAERSAttributed to this product's most-reported active ingredient: IBUPROFEN. Combination products with more than six active ingredients are not attributed, because a report count summed across a long ingredient list measures the list, not the medicine.
Packaging and NDCs
Source: NDC Directory| Package NDC | Product NDC | Labeler | Description | Marketing start |
|---|---|---|---|---|
| 63868-829-40 | 63868-829 | CHAIN DRUG MARKETING ASSOCIATION INC. | 1 BOTTLE, PLASTIC in 1 CARTON (63868-829-40) / 40 CAPSULE, LIQUID FILLED in 1 BOTTLE, PLASTIC | June 11, 2021 |
| 69842-870-15 | 69842-870 | CVS Pharmacy | 1 BOTTLE, PLASTIC in 1 CARTON (69842-870-15) / 40 CAPSULE, LIQUID FILLED in 1 BOTTLE, PLASTIC | October 19, 2021 |
| 69842-913-40 | 69842-913 | CVS Pharmacy | 1 BOTTLE, PLASTIC in 1 BOX (69842-913-40) / 40 CAPSULE, LIQUID FILLED in 1 BOTTLE, PLASTIC | May 29, 2020 |
| 59640-020-15 | 59640-020 | HEB | 1 BOTTLE, PLASTIC in 1 CARTON (59640-020-15) / 40 CAPSULE, LIQUID FILLED in 1 BOTTLE, PLASTIC | March 12, 2026 |
| 30142-232-15 | 30142-232 | KROGER COMPANY | 1 BOTTLE, PLASTIC in 1 CARTON (30142-232-15) / 40 CAPSULE, LIQUID FILLED in 1 BOTTLE, PLASTIC | August 24, 2021 |
| 30142-232-78 | 30142-232 | KROGER COMPANY | 1 BOTTLE, PLASTIC in 1 CARTON (30142-232-78) / 80 CAPSULE, LIQUID FILLED in 1 BOTTLE, PLASTIC | August 24, 2021 |
| 41250-285-15 | 41250-285 | MEIJER DISTRIBUTION INC. | 1 BOTTLE in 1 CARTON (41250-285-15) / 40 CAPSULE, LIQUID FILLED in 1 BOTTLE | October 19, 2022 |
| 41250-285-22 | 41250-285 | MEIJER DISTRIBUTION INC. | 120 CAPSULE, LIQUID FILLED in 1 BOTTLE (41250-285-22) | February 24, 2021 |
| 68016-057-40 | 68016-057 | Premier Value Alliance LLC | 1 BOTTLE in 1 CARTON (68016-057-40) / 40 CAPSULE, LIQUID FILLED in 1 BOTTLE | October 25, 2018 |
| 36800-237-15 | 36800-237 | TOP CARE (Topco Associates LLC) | 1 BOTTLE, PLASTIC in 1 CARTON (36800-237-15) / 40 CAPSULE, LIQUID FILLED in 1 BOTTLE, PLASTIC | October 15, 2021 |
| 36800-756-40 | 36800-756 | TOP CARE (Topco Associates LLC) | 1 BOTTLE, PLASTIC in 1 BOX (36800-756-40) / 40 CAPSULE, LIQUID FILLED in 1 BOTTLE, PLASTIC | July 31, 2018 |
| 0363-0207-11 | 0363-0207 | WALGREEN COMPANY | 1 BOTTLE in 1 CARTON (0363-0207-11) / 20 CAPSULE, LIQUID FILLED in 1 BOTTLE | August 2, 2019 |
| 0363-0207-15 | 0363-0207 | WALGREEN COMPANY | 1 BOTTLE in 1 CARTON (0363-0207-15) / 40 CAPSULE, LIQUID FILLED in 1 BOTTLE | August 2, 2019 |
| 49035-670-15 | 49035-670 | Wal-Mart Stores, Inc. | 1 BOTTLE in 1 CARTON (49035-670-15) / 40 CAPSULE, LIQUID FILLED in 1 BOTTLE | April 1, 2019 |
| 42681-0061-1 | 42681-0061 | Whole Foods Market, INC. | 1 BOTTLE, PLASTIC in 1 CARTON (42681-0061-1) / 40 CAPSULE, LIQUID FILLED in 1 BOTTLE, PLASTIC | May 1, 2026 |
| 63868-829 | 63868-829 | CHAIN DRUG MARKETING ASSOCIATION INC. | — | June 11, 2021 |
| 69842-870 | 69842-870 | CVS Pharmacy | — | October 19, 2021 |
| 69842-913 | 69842-913 | CVS Pharmacy | — | May 29, 2020 |
| 59640-020 | 59640-020 | HEB | — | March 12, 2026 |
| 30142-232 | 30142-232 | KROGER COMPANY | — | August 24, 2021 |
| 41250-285 | 41250-285 | MEIJER DISTRIBUTION INC. | — | February 24, 2021 |
| 68016-057 | 68016-057 | Premier Value Alliance LLC | — | October 25, 2018 |
| 36800-237 | 36800-237 | TOP CARE (Topco Associates LLC) | — | October 15, 2021 |
| 36800-756 | 36800-756 | TOP CARE (Topco Associates LLC) | — | July 31, 2018 |
| 0363-0207 | 0363-0207 | WALGREEN COMPANY | — | August 2, 2019 |
| 49035-670 | 49035-670 | Wal-Mart Stores, Inc. | — | April 1, 2019 |
| 42681-0061 | 42681-0061 | Whole Foods Market, INC. | — | May 1, 2026 |
Sources for this page
| Dataset | Agency | Used for |
|---|---|---|
| NDC Directory | FDA | Identity, ingredients, strengths, forms, routes, labelers, packages |
| Drugs@FDA | FDA | Application, sponsor, submissions, review documents, marketing status |
| Drug Labeling | FDA / NLM | Prescribing information reproduced above |
| FAERS | FDA | Adverse event report counts |
Generated September 25, 2026 · 11 sections on this page.