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Enalapril Maleate

Prescription ANDA TE AB Official labelling
Informational index, not medical advice. Content is reproduced from public FDA and NLM data. Always confirm against the manufacturer's current prescribing information. Report adverse events to FDA MedWatch.

Overview

Brand name
Enalapril Maleate
Generic name
Enalapril Maleate
Dosage form
Tablet
Route
Oral
Marketing category
ANDA · ANDA
Labeler
Bryant Ranch Prepack
Product type
Human Prescription Drug
DEA schedule
Not scheduled
Active ingredients
4
NDC product codes
94
Packages
226
Data completeness
83% of corroborating sources present

Active ingredients

Source: NDC Directory
Active ingredients and strengths as listed in the NDC Directory.
Ingredient Strength RxCUI Monograph
Enalapril Maleate 10 mg/1 1435624 View
Enalapril Maleate 2.5 mg/1 1435624 View
Enalapril Maleate 20 mg/1 1435624 View
Enalapril Maleate 5 mg/1 1435624 View

Forms, strengths and routes

Source: NDC Directory
Dosage form
Tablet
Route of administration
Oral
Presentations
320

Pharmacologic classes are listed in the class section below.

Pharmacologic class

Source: NDC Directory
Established pharmacologic classes (EPC), mechanisms of action (MoA), chemical structures (CS) and physiologic effects (PE).
Class Type Browse
Angiotensin Converting Enzyme Inhibitor [EPC] EPC All 34 members
Angiotensin-converting Enzyme Inhibitors [MoA] MoA All 34 members
Decreased Blood Pressure [PE] PE All 21 members

Regulatory status

Source: Drugs@FDANDC Directory
Application number
213273
Application type
ANDA · Abbreviated New Drug Application
Approval date
July 7, 2022
Sponsor
PRINSTON INC
Products on application
4
Submissions recorded
1
Products approved under application 213273.
Product Trade name Form Strength Ingredient Status TE Flags
213273-001 ENALAPRIL MALEATE TABLET ENALAPRIL MALEATE Prescription AB
213273-002 ENALAPRIL MALEATE TABLET ENALAPRIL MALEATE Prescription AB
213273-003 ENALAPRIL MALEATE TABLET ENALAPRIL MALEATE Prescription AB
213273-004 ENALAPRIL MALEATE TABLET ENALAPRIL MALEATE Prescription AB

Therapeutic equivalence

Source: Orange Book
TE code
AB
Reference Listed Drug
No
Reference Standard
No

What this rating means: Therapeutically equivalent — bioequivalence demonstrated by in vivo or in vitro testing

Codes beginning with “A” indicate products the FDA considers therapeutically equivalent. Codes beginning with “B” indicate bioequivalence has not been established. See methodology.

Approval history

Source: Drugs@FDA
Most recent submissions on application 213273.
Type No. Action Status Date Review
Original application 1 Approved July 7, 2022 Standard

Prescribing information

Source: openFDA Drug Labeling

Reproduced verbatim from the Structured Product Labeling submitted to the FDA (effective 20260410). This is the manufacturer's labelling text, not a summary and not advice.

HUMAN PRESCRIPTION DRUG · 20260410 HUMAN PRESCRIPTION DRUG · 20260410 HUMAN PRESCRIPTION DRUG · 20260131 HUMAN PRESCRIPTION DRUG · 20251010

Boxed Warning

openFDA Drug Labeling

WARNING: FETAL TOXICITY See full prescribing information for complete boxed warning. • When pregnancy is detected, discontinue enalapril maleate tablets as soon as possible. • Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. (See Error! Hyperlink reference not valid..)

Indications and Usage

openFDA Drug Labeling

INDICATIONS AND USAGE Hypertension Enalapril maleate tablets, USP are indicated for the treatment of hypertension. Enalapril maleate tablets, USP are effective alone or in combination with other antihypertensive agents, especially thiazide-type diuretics. The blood pressure lowering effects of enalapril maleate tablets, USP and thiazides are approximately additive. Heart Failure Enalapril maleate tablets, USP are indicated for the treatment of symptomatic congestive heart failure, usually in combination with diuretics and digitalis. In these patients enalapril maleate tablets, USP improve symptoms, increase survival, and decrease the frequency of hospitalization (see CLINICAL PHARMACOLOGY, Heart Failure, Mortality Trials for details and limitations of survival trials). Asymptomatic Left Ventricular Dysfunction In clinically stable asymptomatic patients with left ventricular dysfunction (ejection fraction ≤35 percent), enalapril maleate tablets, USP decrease the rate of development of overt heart failure and decrease the incidence of hospitalization for heart failure (see CLINICAL PHARMACOLOGY, Heart Failure, Mortality Trials for details and limitations of survival trials). In using enalapril maleate tablets, USP consideration should be given to the fact that another angiotensin-converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen vascular disease, and that available data are insufficient to show that enalapril maleate tablets, USP do not have a similar risk (see WARNINGS, Neutropenia/Agranulocytosis ). In considering use of enalapril maleate tablets, USP, it should be noted that in controlled clinical trials ACE inhibitors have an effect on blood pressure that is less in black patients than in non-blacks. In addition, it should be noted that black patients receiving ACE inhibitors have been reported to have a higher incidence of angioedema compared to nonblacks (see WARNINGS, Head and Neck Angioedema ).

Dosage and Administration

openFDA Drug Labeling

DOSAGE AND ADMINISTRATION Hypertension In patients who are currently being treated with a diuretic, symptomatic hypotension occasionally may occur following the initial dose of enalapril maleate tablets. The diuretic should, if possible, be discontinued for two to three days before beginning therapy with enalapril maleate tablets to reduce the likelihood of hypotension (see WARNINGS, Hypotension ). If the patient's blood pressure is not controlled with enalapril maleate tablets alone, diuretic therapy may be resumed. If the diuretic cannot be discontinued an initial dose of 2.5 mg should be used under medical supervision for at least two hours and until blood pressure has stabilized for at least an additional hour (see WARNINGS, Hypotension and PRECAUTIONS, Drug Interactions ). The recommended initial dose in patients not on diuretics is 5 mg once a day. Dosage should be adjusted according to blood pressure response. The usual dosage range is 10 to 40 mg per day administered in a single dose or two divided doses. In some patients treated once daily, the antihypertensive effect may diminish toward the end of the dosing interval. In such patients, an increase in dosage or twice daily administration should be considered. If blood pressure is not controlled with enalapril maleate tablets alone, a diuretic may be added. Concomitant administration of enalapril maleate tablets with potassium supplements, potassium salt substitutes, or potassium-sparing diuretics may lead to increases of serum potassium (see PRECAUTIONS ). Dosage Adjustment in Hypertensive Patients with Renal Impairment The usual dose of enalapril is recommended for patients with a creatinine clearance more than 30 mL/min (serum creatinine of up to approximately 3 mg/dL). For patients with creatinine clearance less than or equal to 30 mL/min (serum creatinine more than or equal to 3 mg/dL), the first dose is 2.5 mg once daily. The dosage may be titrated upward until blood pressure is controlled or to a maximum of 40 mg daily. Renal Status Creatinine Clearance mL/min Initial Dose mg/day Normal Renal Function >80 mL/min 5 mg Mild Impairment ≤ 80 >30 mL/min 5 mg Moderate to Severe Impairment ≤30 mL/min 2.5 mg Dialysis Patients See Error! Hyperlink reference not valid. . 2.5 mg on dialysis days Dosage on nondialysis days should be adjusted depending on the blood pressure response. Heart Failure Enalapril maleate tablets are indicated for the treatment of symptomatic heart failure, usually in combination with diuretics and digitalis. In the placebo-controlled studies that demonstrated improved survival, patients were titrated as tolerated up to 40 mg, administered in two divided doses. The recommended initial dose is 2.5 mg. The recommended dosing range is 2.5 to 20 mg given twice a day. Doses should be titrated upward, as tolerated, over a period of a few days or weeks. The maximum daily dose administered in clinical trials was 40 mg in divided doses. After the initial dose of enalapril maleate tablets, the patient should be observed under medical supervision for at least two hours and until blood pressure has stabilized for at least an additional hour (see WARNINGS and PRECAUTIONS, Drug Interactions ). If possible, the dose of any concomitant diuretic should be reduced which may diminish the likelihood of hypotension. The appearance of hypotension after the initial dose of enalapril maleate tablets does not preclude subsequent careful dose titration with the drug, following effective management of the hypotension. Asymptomatic Left Ventricular Dysfunction In the trial that demonstrated efficacy, patients were started on 2.5 mg twice daily and were titrated as tolerated to the targeted daily dose of 20 mg (in divided doses). After the initial dose of enalapril maleate tablets, the patient should be observed under medical supervision for at least two hours and until blood pressure has stabilized for at least an additional hour (see WARNINGS and PRECAUTIONS, Drug Interactio …

Contraindications

openFDA Drug Labeling

CONTRAINDICATIONS Enalapril maleate tablets, USP are contraindicated in patients who are hypersensitive to this product and in patients with a history of angioedema related to previous treatment with an angiotensin-converting enzyme inhibitor and in patients with hereditary or idiopathic angioedema. Do not coadminister aliskiren with enalapril maleate in patients with diabetes (see PRECAUTIONS, Drug Interactions ). Enalapril maleate tablets, USP are contraindicated in combination with a neprilysin inhibitor (e.g., sacubitril). Do not administer enalapril maleate tablets USP within 36 hours of switching to or from sacubitril/valsartan, a neprilysin inhibitor (see WARNINGS , Head and Neck Angioedema ).

WARNINGS Anaphylactoid and Possibly Related Reactions Presumably because angiotensin-converting enzyme inhibitors affect the metabolism of eicosanoids and polypeptides, including endogenous bradykinin, patients receiving ACE inhibitors (including Enalapril Maleate Tablets) may be subject to a variety of adverse reactions, some of them serious. Head and Neck Angioedema Angioedema of the face, extremities, lips, tongue, glottis and/or larynx has been reported in patients treated with angiotensin-converting enzyme inhibitors, including Enalapril Maleate Tablets. This may occur at any time during treatment. In such cases Enalapril Maleate Tablets should be promptly discontinued and appropriate therapy and monitoring should be provided until complete and sustained resolution of signs and symptoms has occurred. In instances where swelling has been confined to the face and lips the condition has generally resolved without treatment, although antihistamines have been useful in relieving symptoms. Angioedema associated with laryngeal edema may be fatal. Where there is involvement of the tongue, glottis or larynx, likely to cause airway obstruction, appropriate therapy, e.g., subcutaneous epinephrine solution 1:1000 (0.3 mL to 0.5 mL) and/or measures necessary to ensure a patent airway, should be promptly provided (see ADVERSE REACTIONS ). Patients receiving coadministration of ACE inhibitor and mTOR (mammalian target of rapamycin) inhibitor (e.g., temsirolimus, sirolimus, everolimus) therapy or a neprilysin inhibitor may be at increased risk for angioedema (see PRECAUTIONS ). Intestinal Angioedema : Intestinal angioedema has been reported in patients treated with ACE inhibitors. These patients presented with abdominal pain (with or without nausea or vomiting); in some cases there was no prior history of facial angioedema and C1 esterase levels were normal. The angioedema was diagnosed by procedures including abdominal CT scan or ultrasound, or at surgery, and symptoms resolved after stopping the ACE inhibitor. Intestinal angioedema should be included in the differential diagnosis of patients on ACE inhibitors presenting with abdominal pain. Patients with a history of angioedema unrelated to ACE inhibitor therapy may be at increased risk of angioedema while receiving an ACE inhibitor (see INDICATIONS AND USAGE and CONTRAINDICATIONS ). Anaphylactoid Reactions During Desensitization Two patients undergoing desensitizing treatment with hymenoptera venom while receiving ACE inhibitors sustained life-threatening anaphylactoid reactions. In the same patients, these reactions were avoided when ACE inhibitors were temporarily withheld, but they reappeared upon inadvertent rechallenge. Anaphylactoid Reactions During Membrane Exposure Anaphylactoid reactions have been reported in patients dialyzed with high-flux membranes and treated concomitantly with an ACE inhibitor. Anaphylactoid reactions have also been reported in patients undergoing low-density lipoprotein apheresis with dextran sulfate absorption. Hypotension Excessive hypotension is rare in uncomplicated hypertensive patients treated with Enalapril Maleate Tablets alone. Patients with heart failure given Enalapril Maleate Tablets commonly have some reduction in blood pressure, especially with the first dose, but discontinuation of therapy for continuing symptomatic hypotension usually is not necessary when dosing instructions are followed; caution should be observed when initiating therapy (see DOSAGE AND ADMINISTRATION ). Patients at risk for excessive hypotension, sometimes associated with oliguria and/or progressive azotemia, and rarely with acute renal failure and/or death, include those with the following conditions or characteristics: heart failure, hyponatremia, high-dose diuretic therapy, recent intensive diuresis or increase in diuretic dose, renal dialysis, or severe volume and/or salt depletion of any etiology. It may be advisable to eliminate the diuretic (except in patients …

Adverse Reactions

openFDA Drug Labeling

ADVERSE REACTIONS Enalapril maleate tablets have been evaluated for safety in more than 10,000 patients, including over 1000 patients treated for one year or more. Enalapril maleate tablets have been found to be generally well tolerated in controlled clinical trials involving 2987 patients. For the most part, adverse experiences were mild and transient in nature. In clinical trials, discontinuation of therapy due to clinical adverse experiences was required in 3.3 percent of patients with hypertension and in 5.7 percent of patients with heart failure. The frequency of adverse experiences was not related to total daily dosage within the usual dosage ranges. In patients with hypertension the overall percentage of patients treated with enalapril maleate tablets reporting adverse experiences was comparable to placebo. Hypertension Adverse experiences occurring in greater than one percent of patients with hypertension treated with enalapril maleate tablets in controlled clinical trials are shown below. In patients treated with enalapril maleate tablets, the maximum duration of therapy was three years; in placebo-treated patients the maximum duration of therapy was 12 weeks. Enalapril Maleate Tablets (n=2314) Incidence (discontinuation) Placebo (n=230) Incidence Body As A Whole Fatigue 3.0 (<0.1) 2.6 Orthostatic Effects 1.2 (<0.1) 0.0 Asthenia 1.1 (0.1) 0.9 Digestive Diarrhea 1.4 (<0.1) 1.7 Nausea 1.4 (0.2) 1.7 Nervous/Psychiatric Headache 5.2 (0.3) 9.1 Dizziness 4.3 (0.4) 4.3 Respiratory Cough 1.3 (0.1) 0.9 Skin Rash 1.4 (0.4) 0.4 Heart Failure Adverse experiences occurring in greater than one percent of patients with heart failure treated with enalapril maleate tablets are shown below. The incidences represent the experiences from both controlled and uncontrolled clinical trials (maximum duration of therapy was approximately one year). In the placebo-treated patients, the incidences reported are from the controlled trials (maximum duration of therapy is 12 weeks). The percentage of patients with severe heart failure (NYHA Class IV) was 29 percent and 43 percent for patients treated with enalapril maleate tablets and placebo, respectively. Enalapril Maleate Tablets (n=673) Incidence (discontinuation) Placebo (n=339) Incidence Body As A Whole Orthostatic Effects 2.2 (0.1) 0.3 Syncope 2.2 (0.1) 0.9 Chest Pain 2.1 (0.0) 2.1 Fatigue 1.8 (0.0) 1.8 Abdominal Pain 1.6 (0.4) 2.1 Asthenia 1.6 (0.1) 0.3 Cardiovascular Hypotension 6.7 (1.9) 0.6 Orthostatic Hypotension 1.6 (0.1) 0.3 Angina Pectoris 1.5 (0.1) 1.8 Myocardial Infarction 1.2 (0.3) 1.8 Digestive Diarrhea 2.1 (0.1) 1.2 Nausea 1.3 (0.1) 0.6 Vomiting 1.3 (0.0) 0.9 Nervous/Psychiatric Dizziness 7.9 (0.6) 0.6 Headache 1.8 (0.1) 0.9 Vertigo 1.6 (0.1) 1.2 Respiratory Cough 2.2 (0.0) 0.6 Bronchitis 1.3 (0.0) 0.9 Dyspnea 1.3 (0.1) 0.4 Pneumonia 1.0 (0.0) 2.4 Skin Rash 1.3 (0.0) 2.4 Urogenital Urinary Tract Infection 1.3 (0.0) 2.4 Other serious clinical adverse experiences occurring since the drug was marketed or adverse experiences occurring in 0.5 to 1.0 percent of patients with hypertension or heart failure in clinical trials are listed below and, within each category, are in order of decreasing severity. Body As A Whole: Anaphylactoid reactions (see Error! Hyperlink reference not valid. ). Cardiovascular: Cardiac arrest; myocardial infarction or cerebrovascular accident, possibly secondary to excessive hypotension in high risk patients (see WARNINGS, Hypotension ); pulmonary embolism and infarction; pulmonary edema; rhythm disturbances including atrial tachycardia and bradycardia; atrial fibrillation; palpitation, Raynaud's phenomenon. Digestive: Ileus, pancreatitis, hepatic failure, hepatitis (hepatocellular [proven on rechallenge] or cholestatic jaundice) (see Error! Hyperlink reference not valid. ), melena, anorexia, dyspepsia, constipation, glossitis, stomatitis, dry mouth. Hematologic: Rare cases of neutropenia, thrombocytopenia and bone marrow depression. Musculoskeletal: Muscle cr …

Drug Interactions

openFDA Drug Labeling

Drug Interactions Neprilysin Inhibitors Patients taking concomitant neprilysin inhibitors may be at increased risk for angioedema (see WARNINGS ). Dual Blockade of the Renin-Angiotensin System (RAS) Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Most patients receiving the combination of two RAS inhibitors do not obtain any additional benefit compared to monotherapy. In general, avoid combined use of RAS inhibitors. Closely monitor blood pressure, renal function, and electrolytes in patients on enalapril maleate tablets and other agents that affect the RAS. Do not coadminister aliskiren with enalapril maleate tablets in patients with diabetes. Avoid use of aliskiren with enalapril maleate tablets in patients with renal impairment (GFR <60 mL/min). Hypotension — Patients on Diuretic Therapy Patients on diuretics and especially those in whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with enalapril. The possibility of hypotensive effects with enalapril can be minimized by either discontinuing the diuretic or increasing the salt intake prior to initiation of treatment with enalapril. If it is necessary to continue the diuretic, provide close medical supervision after the initial dose for at least two hours and until blood pressure has stabilized for at least an additional hour (see WARNINGS, Hypotension and DOSAGE AND ADMINISTRATION ). Agents Causing Renin Release The antihypertensive effect of enalapril maleate tablets is augmented by antihypertensive agents that cause renin release (e.g., diuretics). Nonsteroidal Anti-Inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration of renal function, including possible acute renal failure. These effects are usually reversible. Monitor renal function periodically in patients receiving enalapril and NSAID therapy. In a clinical pharmacology study, indomethacin or sulindac was administered to hypertensive patients receiving enalapril maleate tablets. In this study there was no evidence of a blunting of the antihypertensive action of enalapril maleate tablets. However, reports suggest that NSAIDs may diminish the antihypertensive effect of ACE inhibitors. Other Cardiovascular Agents Enalapril maleate tablets have been used concomitantly with beta adrenergic-blocking agents, methyldopa, nitrates, calcium-blocking agents, hydralazine, prazosin and digoxin without evidence of clinically significant adverse interactions. Agents Increasing Serum Potassium Enalapril maleate tablets attenuate potassium loss caused by thiazide-type diuretics. Potassium-sparing diuretics (e.g., spironolactone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium. Therefore, if concomitant use of these agents is indicated because of demonstrated hypokalemia, they should be used with caution and with frequent monitoring of serum potassium. Potassium-sparing agents should generally not be used in patients with heart failure receiving enalapril maleate tablets. Lithium Lithium toxicity has been reported in patients receiving lithium concomitantly with drugs which cause elimination of sodium, including ACE inhibitors. A few cases of lithium toxicity have been reported in patients receiving concomitant enalapril maleate tablets and lithium and were reversible upon discontinuation of both drugs. It is recommended that serum lithium levels be monitored frequently if …

Mechanism of Action

openFDA Drug Labeling

Mechanism of Action Enalapril, after hydrolysis to enalaprilat, inhibits angiotensin-converting enzyme (ACE) in human subjects and animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. The beneficial effects of enalapril in hypertension and heart failure appear to result primarily from suppression of the renin-angiotensin-aldosterone system. Inhibition of ACE results in decreased plasma angiotensin II, which leads to decreased vasopressor activity and to decreased aldosterone secretion. Although the latter decrease is small, it results in small increases of serum potassium. In hypertensive patients treated with enalapril maleate tablets alone for up to 48 weeks, mean increases in serum potassium of approximately 0.2 mEq/L were observed. In patients treated with enalapril maleate tablets plus a thiazide diuretic, there was essentially no change in serum potassium (see PRECAUTIONS ). Removal of angiotensin II negative feedback on renin secretion leads to increased plasma renin activity. ACE is identical to kininase, an enzyme that degrades bradykinin. Whether increased levels of bradykinin, a potent vasodepressor peptide, play a role in the therapeutic effects of enalapril maleate tablets remains to be elucidated. While the mechanism through which enalapril maleate tablets lower blood pressure is believed to be primarily suppression of the renin-angiotensin-aldosterone system, enalapril maleate tablets are antihypertensive even in patients with low-renin hypertension. Although enalapril maleate tablets were antihypertensive in all races studied, black hypertensive patients (usually a low-renin hypertensive population) had a smaller average response to enalapril monotherapy than non-black patients.

Description

openFDA Drug Labeling

DESCRIPTION Enalapril maleate, USP is the maleate salt of enalapril, the ethyl ester of a long-acting angiotensin-converting enzyme inhibitor, enalaprilat. Enalapril maleate is chemically described as L–Proline, 1–[N-[1-(ethoxycarbonyl)–3–phenylpropyl]–L–alanyl]-,(S)-,(Z)-2-butenedioate(1:1). Its empirical formula is C 20 H 28 N 2 O 5 ●C 4 H 4 O 4 , and its structural formula is: Enalapril maleate, USP is an off-white, crystalline powder with a molecular weight of 492.52. It is practically insoluble in n-Heptane (non-polar organic solvents), slightly soluble in Acetone (semi polar organic solvents), sparingly soluble in water, soluble in alcohol, freely soluble in methanol and in dimethyl formamide. Enalapril is a pro-drug; following oral administration, it is bioactivated by hydrolysis of the ethyl ester to enalaprilat, which is the active angiotensin-converting enzyme inhibitor. Enalapril maleate, USP is supplied as 2.5 mg, 5 mg, 10 mg, and 20 mg tablets for oral administration. In addition to the active ingredient enalapril maleate, USP each tablet contains the following inactive ingredients: croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol 4000, pregelatinised starch, sodium bicarbonate and sodium stearate. The 10 mg tablets also contain red iron oxide, and 20 mg tablets also contain yellow iron oxide and red iron oxide. FDA approved dissolution test specifications differs from the USP. enalapril-maleate-stru

OVERDOSAGE Limited data are available in regard to overdosage in humans. Single oral doses of enalapril above 1,000 mg/kg and ≥1,775 mg/kg were associated with lethality in mice and rats, respectively. The most likely manifestation of overdosage would be hypotension, for which the usual treatment would be intravenous infusion of normal saline solution. Enalaprilat may be removed from general circulation by hemodialysis and has been removed from neonatal circulation by peritoneal dialysis (see WARNINGS , Anaphylactoid Reactions During Membrane Exposure ).

How Supplied / Storage and Handling

openFDA Drug Labeling

HOW SUPPLIED Enalapril Maleate Tablets, USP NDC Number Strength Quantity Description 43547-545-03 2.5 mg Bottles of 30 with child-resistant closure (with desiccant) White, oval shaped scored tablet, debossed with “S 1” and scored on one side, “S” and “1” are separated by the score and plain on the other side. 43547-545-09 Bottles of 90 with child-resistant closure (with desiccant) 43547-545-10 Bottles of 100 with child-resistant closure (with desiccant) 43547-545-50 Bottles of 500 with child-resistant closure (with desiccant) 43547-545-11 Bottles of 1,000 (with desiccant) 43547-546-03 5 mg Bottles of 30 with child-resistant closure (with desiccant) White, rounded triangle shaped scored tablet debossed with “S 6” on one side and scored on the other side. 43547-546-09 Bottles of 90 with child-resistant closure (with desiccant) 43547-546-10 Bottles of 100 with child-resistant closure (with desiccant) 43547-546-50 Bottles of 500 (with desiccant) 43547-546-11 Bottles of 1,000 (with desiccant) 43547-547-03 10 mg Bottles of 30 with child-resistant closure (with desiccant) Red, rounded triangle shaped scored tablet debossed with “S 7” on one side and scored on the other side. 43547-547-09 Bottles of 90 with child-resistant closure (with desiccant) 43547-547-10 Bottles of 100 with child-resistant closure (with desiccant) 43547-547-50 Bottles of 500 (with desiccant) 43547-547-11 Bottles of 1,000 (with desiccant) 43547-548-03 20 mg Bottles of 30 with child-resistant closure (with desiccant) Yellow, round scored tablet, debossed with “S 11” and scored on one side, “S 11” is on one side of the score and plain on the other side. 43547-548-09 Bottles of 90 with child-resistant closure (with desiccant) 43547-548-10 Bottles of 100 with child-resistant closure (with desiccant) 43547-548-50 Bottles of 500 (with desiccant) 43547-548-11 Bottles of 1,000 (with desiccant) Storage Store at 20 o to 25 o C (68 o to 77 o F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature]. Keep container tightly closed. Protect from moisture. Dispense in a tight container as per USP, if product package is subdivided. Manufactured by: Zhejiang Huahai Pharmaceutical Co., Ltd. Xunqiao, Linhai, Zhejiang 317024, China Zhejiang Huahai Pharmaceutical Technology Co., Ltd. Jiangnan, Linhai, Zhejiang 317000, China Distributed by: Solco Healthcare US, LLC Somerset, NJ 08873, USA Revised: 01/2026

Adverse event reports

Source: openFDA FAERS
25,496
FAERS reports mentioning this drug
as of 2026-09-25T03:42:24+00:00
A report count is not a risk measure. FAERS accepts voluntary and mandatory reports without establishing causation, and reporting is influenced by how widely a drug is used, how long it has been marketed, and media attention. FDA states that reports “do not prove that the drug caused the event”. Compare rates, not totals.

Attributed to this product's most-reported active ingredient: ENALAPRIL MALEATE. Combination products with more than six active ingredients are not attributed, because a report count summed across a long ingredient list measures the list, not the medicine.

Recalls

Source: FDA Enforcement
Drug recall enforcement reports associated with this product.
Classification Reported Firm Reason Status
Class II May 13, 2026 JB Chemicals and Pharmaceuticals Ltd Failed Impurities/Degradation Specifications:Out of specification result occurred in Organic Impurities Test Ongoing
Class II July 13, 2022 Golden State Medical Supply Inc. CGMP Deviations Ongoing
Class II July 13, 2022 Golden State Medical Supply Inc. CGMP Deviations Ongoing
Class II July 13, 2022 Golden State Medical Supply Inc. CGMP Deviations Ongoing
Class II July 13, 2022 Golden State Medical Supply Inc. CGMP Deviations Ongoing

Packaging and NDCs

Source: NDC Directory
Every National Drug Code package associated with this medication. The NDC is the identifier used for dispensing, billing and pharmacovigilance in the United States.
Package NDC Product NDC Labeler Description Marketing start
50090-3378-0 50090-3378 A-S Medication Solutions 30 TABLET in 1 BOTTLE, PLASTIC (50090-3378-0) November 28, 2014
50090-3378-1 50090-3378 A-S Medication Solutions 100 TABLET in 1 BOTTLE (50090-3378-1) February 22, 2018
50090-3378-3 50090-3378 A-S Medication Solutions 90 TABLET in 1 BOTTLE (50090-3378-3) November 19, 2022
50090-4560-0 50090-4560 A-S Medication Solutions 30 TABLET in 1 BOTTLE (50090-4560-0) September 26, 2019
50090-4560-1 50090-4560 A-S Medication Solutions 60 TABLET in 1 BOTTLE (50090-4560-1) September 26, 2019
50090-4560-3 50090-4560 A-S Medication Solutions 90 TABLET in 1 BOTTLE (50090-4560-3) September 26, 2019
50090-6437-0 50090-6437 A-S Medication Solutions 30 TABLET in 1 BOTTLE (50090-6437-0) April 14, 2023
50090-6437-1 50090-6437 A-S Medication Solutions 60 TABLET in 1 BOTTLE (50090-6437-1) April 26, 2023
50090-6437-3 50090-6437 A-S Medication Solutions 90 TABLET in 1 BOTTLE (50090-6437-3) April 26, 2023
50090-6490-0 50090-6490 A-S Medication Solutions 30 TABLET in 1 BOTTLE (50090-6490-0) May 18, 2023
50090-6490-1 50090-6490 A-S Medication Solutions 100 TABLET in 1 BOTTLE (50090-6490-1) May 18, 2023
50090-6490-3 50090-6490 A-S Medication Solutions 90 TABLET in 1 BOTTLE (50090-6490-3) May 18, 2023
50090-6712-0 50090-6712 A-S Medication Solutions 30 TABLET in 1 BOTTLE (50090-6712-0) September 28, 2023
50090-6712-1 50090-6712 A-S Medication Solutions 100 TABLET in 1 BOTTLE (50090-6712-1) September 28, 2023
50090-6712-4 50090-6712 A-S Medication Solutions 90 TABLET in 1 BOTTLE (50090-6712-4) September 28, 2023
50090-7222-0 50090-7222 A-S Medication Solutions 30 TABLET in 1 BOTTLE (50090-7222-0) August 13, 2024
50090-7222-1 50090-7222 A-S Medication Solutions 100 TABLET in 1 BOTTLE (50090-7222-1) August 13, 2024
50090-7222-3 50090-7222 A-S Medication Solutions 90 TABLET in 1 BOTTLE (50090-7222-3) August 13, 2024
50090-7302-0 50090-7302 A-S Medication Solutions 30 TABLET in 1 BOTTLE (50090-7302-0) October 14, 2024
50090-7302-1 50090-7302 A-S Medication Solutions 100 TABLET in 1 BOTTLE (50090-7302-1) October 14, 2024
50090-7302-3 50090-7302 A-S Medication Solutions 90 TABLET in 1 BOTTLE (50090-7302-3) October 14, 2024
50090-7677-0 50090-7677 A-S Medication Solutions 30 TABLET in 1 BOTTLE (50090-7677-0) October 8, 2025
50090-7677-1 50090-7677 A-S Medication Solutions 60 TABLET in 1 BOTTLE (50090-7677-1) October 8, 2025
50090-7677-3 50090-7677 A-S Medication Solutions 90 TABLET in 1 BOTTLE (50090-7677-3) October 8, 2025
50090-7678-0 50090-7678 A-S Medication Solutions 30 TABLET in 1 BOTTLE (50090-7678-0) October 8, 2025
50090-7678-1 50090-7678 A-S Medication Solutions 100 TABLET in 1 BOTTLE (50090-7678-1) October 8, 2025
50090-7678-4 50090-7678 A-S Medication Solutions 90 TABLET in 1 BOTTLE (50090-7678-4) October 8, 2025
69292-540-01 69292-540 Amici Pharma, Inc 100 TABLET in 1 BOTTLE (69292-540-01) October 15, 2025
69292-540-10 69292-540 Amici Pharma, Inc 1000 TABLET in 1 BOTTLE (69292-540-10) October 15, 2025
69292-542-01 69292-542 Amici Pharma, Inc 100 TABLET in 1 BOTTLE (69292-542-01) October 15, 2025
69292-542-10 69292-542 Amici Pharma, Inc 1000 TABLET in 1 BOTTLE (69292-542-10) October 15, 2025
69292-542-50 69292-542 Amici Pharma, Inc 500 TABLET in 1 BOTTLE (69292-542-50) September 5, 2026
69292-544-01 69292-544 Amici Pharma, Inc 100 TABLET in 1 BOTTLE (69292-544-01) October 15, 2025
69292-544-10 69292-544 Amici Pharma, Inc 1000 TABLET in 1 BOTTLE (69292-544-10) October 15, 2025
69292-544-50 69292-544 Amici Pharma, Inc 500 TABLET in 1 BOTTLE (69292-544-50) September 5, 2026
69292-546-01 69292-546 Amici Pharma, Inc 100 TABLET in 1 BOTTLE (69292-546-01) October 15, 2025
69292-546-10 69292-546 Amici Pharma, Inc 1000 TABLET in 1 BOTTLE (69292-546-10) October 15, 2025
63629-7895-1 63629-7895 Bryant Ranch Prepack 30 TABLET in 1 BOTTLE (63629-7895-1) January 15, 2019
63629-7895-2 63629-7895 Bryant Ranch Prepack 90 TABLET in 1 BOTTLE (63629-7895-2) January 15, 2019
71335-1910-1 71335-1910 Bryant Ranch Prepack 150 TABLET in 1 BOTTLE (71335-1910-1) August 20, 2026
71335-1910-2 71335-1910 Bryant Ranch Prepack 100 TABLET in 1 BOTTLE (71335-1910-2) October 27, 2023
71335-1910-3 71335-1910 Bryant Ranch Prepack 30 TABLET in 1 BOTTLE (71335-1910-3) September 17, 2021
71335-1910-4 71335-1910 Bryant Ranch Prepack 60 TABLET in 1 BOTTLE (71335-1910-4) August 20, 2026
71335-1910-5 71335-1910 Bryant Ranch Prepack 90 TABLET in 1 BOTTLE (71335-1910-5) August 11, 2021
71335-1910-6 71335-1910 Bryant Ranch Prepack 10 TABLET in 1 BOTTLE (71335-1910-6) August 20, 2026
71335-2252-1 71335-2252 Bryant Ranch Prepack 30 TABLET in 1 BOTTLE (71335-2252-1) August 20, 2026
71335-2252-2 71335-2252 Bryant Ranch Prepack 90 TABLET in 1 BOTTLE (71335-2252-2) August 20, 2026
71335-2382-1 71335-2382 Bryant Ranch Prepack 150 TABLET in 1 BOTTLE (71335-2382-1) July 8, 2024
71335-2382-2 71335-2382 Bryant Ranch Prepack 100 TABLET in 1 BOTTLE (71335-2382-2) July 8, 2024
71335-2382-3 71335-2382 Bryant Ranch Prepack 30 TABLET in 1 BOTTLE (71335-2382-3) July 8, 2024
71335-2382-4 71335-2382 Bryant Ranch Prepack 60 TABLET in 1 BOTTLE (71335-2382-4) July 8, 2024
71335-2382-5 71335-2382 Bryant Ranch Prepack 90 TABLET in 1 BOTTLE (71335-2382-5) July 8, 2024
71335-2608-1 71335-2608 Bryant Ranch Prepack 60 TABLET in 1 BOTTLE (71335-2608-1) August 24, 2026
71335-2608-2 71335-2608 Bryant Ranch Prepack 30 TABLET in 1 BOTTLE (71335-2608-2) February 24, 2025
71335-2608-3 71335-2608 Bryant Ranch Prepack 100 TABLET in 1 BOTTLE (71335-2608-3) August 24, 2026
71335-2608-4 71335-2608 Bryant Ranch Prepack 90 TABLET in 1 BOTTLE (71335-2608-4) March 4, 2025
71335-2608-5 71335-2608 Bryant Ranch Prepack 120 TABLET in 1 BOTTLE (71335-2608-5) August 24, 2026
71335-3085-1 71335-3085 Bryant Ranch Prepack 30 TABLET in 1 BOTTLE (71335-3085-1) February 16, 2026
71335-3085-2 71335-3085 Bryant Ranch Prepack 90 TABLET in 1 BOTTLE (71335-3085-2) February 16, 2026
71335-3136-1 71335-3136 Bryant Ranch Prepack 60 TABLET in 1 BOTTLE (71335-3136-1) May 27, 2026
71335-3136-2 71335-3136 Bryant Ranch Prepack 30 TABLET in 1 BOTTLE (71335-3136-2) May 27, 2026
71335-3136-3 71335-3136 Bryant Ranch Prepack 100 TABLET in 1 BOTTLE (71335-3136-3) May 27, 2026
71335-3136-4 71335-3136 Bryant Ranch Prepack 90 TABLET in 1 BOTTLE (71335-3136-4) May 27, 2026
71335-3136-5 71335-3136 Bryant Ranch Prepack 120 TABLET in 1 BOTTLE (71335-3136-5) May 27, 2026
71335-3164-1 71335-3164 Bryant Ranch Prepack 150 TABLET in 1 BOTTLE (71335-3164-1) August 4, 2026
71335-3164-2 71335-3164 Bryant Ranch Prepack 100 TABLET in 1 BOTTLE (71335-3164-2) August 4, 2026
71335-3164-3 71335-3164 Bryant Ranch Prepack 30 TABLET in 1 BOTTLE (71335-3164-3) August 4, 2026
71335-3164-4 71335-3164 Bryant Ranch Prepack 60 TABLET in 1 BOTTLE (71335-3164-4) August 4, 2026
71335-3164-5 71335-3164 Bryant Ranch Prepack 90 TABLET in 1 BOTTLE (71335-3164-5) August 4, 2026
71335-3164-6 71335-3164 Bryant Ranch Prepack 10 TABLET in 1 BOTTLE (71335-3164-6) August 4, 2026
71335-9604-1 71335-9604 Bryant Ranch Prepack 60 TABLET in 1 BOTTLE (71335-9604-1) December 20, 2022
71335-9604-2 71335-9604 Bryant Ranch Prepack 30 TABLET in 1 BOTTLE (71335-9604-2) December 20, 2022
71335-9604-3 71335-9604 Bryant Ranch Prepack 100 TABLET in 1 BOTTLE (71335-9604-3) December 20, 2022
71335-9604-4 71335-9604 Bryant Ranch Prepack 90 TABLET in 1 BOTTLE (71335-9604-4) December 20, 2022
71335-9604-5 71335-9604 Bryant Ranch Prepack 120 TABLET in 1 BOTTLE (71335-9604-5) December 20, 2022
71335-9649-1 71335-9649 Bryant Ranch Prepack 100 TABLET in 1 BOTTLE (71335-9649-1) April 3, 2024
71335-9649-2 71335-9649 Bryant Ranch Prepack 60 TABLET in 1 BOTTLE (71335-9649-2) April 3, 2024
71335-9649-3 71335-9649 Bryant Ranch Prepack 30 TABLET in 1 BOTTLE (71335-9649-3) March 24, 2023
71335-9649-4 71335-9649 Bryant Ranch Prepack 90 TABLET in 1 BOTTLE (71335-9649-4) February 13, 2023
71335-9698-1 71335-9698 Bryant Ranch Prepack 100 TABLET in 1 BOTTLE (71335-9698-1) May 11, 2023
71335-9698-2 71335-9698 Bryant Ranch Prepack 60 TABLET in 1 BOTTLE (71335-9698-2) May 11, 2023
71335-9698-3 71335-9698 Bryant Ranch Prepack 30 TABLET in 1 BOTTLE (71335-9698-3) May 11, 2023
71335-9698-4 71335-9698 Bryant Ranch Prepack 90 TABLET in 1 BOTTLE (71335-9698-4) May 11, 2023
62135-589-90 62135-589 Chartwell RX, LLC 90 TABLET in 1 BOTTLE (62135-589-90) April 27, 2023
62135-590-90 62135-590 Chartwell RX, LLC 90 TABLET in 1 BOTTLE (62135-590-90) April 27, 2023
62135-591-90 62135-591 Chartwell RX, LLC 90 TABLET in 1 BOTTLE (62135-591-90) April 27, 2023
62135-592-90 62135-592 Chartwell RX, LLC 90 TABLET in 1 BOTTLE (62135-592-90) April 27, 2023
67046-0798-3 67046-0798 Coupler LLC 30 TABLET in 1 BLISTER PACK (67046-0798-3) April 28, 2026
67046-1254-3 67046-1254 Coupler LLC 30 TABLET in 1 BLISTER PACK (67046-1254-3) August 26, 2026
67046-1504-3 67046-1504 Coupler LLC 30 TABLET in 1 BLISTER PACK (67046-1504-3) January 28, 2025
51407-828-10 51407-828 Golden State Medical Supply, Inc. 1000 TABLET in 1 BOTTLE (51407-828-10) October 9, 2023
51407-828-90 51407-828 Golden State Medical Supply, Inc. 90 TABLET in 1 BOTTLE (51407-828-90) October 9, 2023
60429-183-10 60429-183 Golden State Medical Supply, Inc. 1000 TABLET in 1 BOTTLE (60429-183-10) November 4, 2013
60429-183-90 60429-183 Golden State Medical Supply, Inc. 90 TABLET in 1 BOTTLE (60429-183-90) November 4, 2013
60429-184-10 60429-184 Golden State Medical Supply, Inc. 1000 TABLET in 1 BOTTLE (60429-184-10) November 4, 2013
60429-184-90 60429-184 Golden State Medical Supply, Inc. 90 TABLET in 1 BOTTLE (60429-184-90) November 4, 2013
60429-186-10 60429-186 Golden State Medical Supply, Inc. 1000 TABLET in 1 BOTTLE (60429-186-10) November 4, 2013
60429-186-90 60429-186 Golden State Medical Supply, Inc. 90 TABLET in 1 BOTTLE (60429-186-90) November 4, 2013
23155-704-01 23155-704 Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. 100 TABLET in 1 BOTTLE (23155-704-01) April 28, 2020
23155-704-10 23155-704 Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. 1000 TABLET in 1 BOTTLE (23155-704-10) April 28, 2020
23155-705-01 23155-705 Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. 100 TABLET in 1 BOTTLE (23155-705-01) April 28, 2020
23155-705-10 23155-705 Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. 1000 TABLET in 1 BOTTLE (23155-705-10) April 28, 2020
23155-772-01 23155-772 Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. 100 TABLET in 1 BOTTLE (23155-772-01) October 1, 2020
23155-772-10 23155-772 Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. 1000 TABLET in 1 BOTTLE (23155-772-10) October 1, 2020
23155-773-01 23155-773 Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. 100 TABLET in 1 BOTTLE (23155-773-01) October 1, 2020
23155-773-05 23155-773 Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. 500 TABLET in 1 BOTTLE (23155-773-05) October 1, 2020
23155-773-10 23155-773 Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. 1000 TABLET in 1 BOTTLE (23155-773-10) October 1, 2020
68645-605-90 68645-605 Legacy Pharmaceutical Packaging, LLC 90 TABLET in 1 BOTTLE (68645-605-90) November 14, 2022
68645-606-90 68645-606 Legacy Pharmaceutical Packaging, LLC 90 TABLET in 1 BOTTLE (68645-606-90) November 14, 2022
68645-607-90 68645-607 Legacy Pharmaceutical Packaging, LLC 90 TABLET in 1 BOTTLE (68645-607-90) November 14, 2022
0904-7309-61 0904-7309 Major Pharmaceuticals 100 BLISTER PACK in 1 CARTON (0904-7309-61) / 1 TABLET in 1 BLISTER PACK August 28, 2025
0904-7310-61 0904-7310 Major Pharmaceuticals 100 BLISTER PACK in 1 CARTON (0904-7310-61) / 1 TABLET in 1 BLISTER PACK August 28, 2025
0904-7311-61 0904-7311 Major Pharmaceuticals 100 BLISTER PACK in 1 CARTON (0904-7311-61) / 1 TABLET in 1 BLISTER PACK August 28, 2025
0904-7312-61 0904-7312 Major Pharmaceuticals 100 BLISTER PACK in 1 CARTON (0904-7312-61) / 1 TABLET in 1 BLISTER PACK August 28, 2025
16714-442-01 16714-442 Northstar RxLLC 100 TABLET in 1 BOTTLE (16714-442-01) August 6, 2015
16714-442-02 16714-442 Northstar RxLLC 1000 TABLET in 1 BOTTLE (16714-442-02) August 6, 2015
16714-443-01 16714-443 Northstar RxLLC 100 TABLET in 1 BOTTLE (16714-443-01) August 6, 2015
16714-443-02 16714-443 Northstar RxLLC 1000 TABLET in 1 BOTTLE (16714-443-02) August 6, 2015
16714-444-01 16714-444 Northstar RxLLC 100 TABLET in 1 BOTTLE (16714-444-01) August 6, 2015
16714-444-02 16714-444 Northstar RxLLC 1000 TABLET in 1 BOTTLE (16714-444-02) August 6, 2015
16714-445-01 16714-445 Northstar RxLLC 100 TABLET in 1 BOTTLE (16714-445-01) August 6, 2015
16714-445-02 16714-445 Northstar RxLLC 1000 TABLET in 1 BOTTLE (16714-445-02) August 6, 2015
51655-006-26 51655-006 Northwind Health Company, LLC 90 TABLET in 1 BOTTLE, PLASTIC (51655-006-26) September 6, 2022
51655-006-52 51655-006 Northwind Health Company, LLC 30 TABLET in 1 BOTTLE, PLASTIC (51655-006-52) July 11, 2022
51655-058-26 51655-058 Northwind Health Company, LLC 90 TABLET in 1 BOTTLE, PLASTIC (51655-058-26) July 11, 2022
51655-058-52 51655-058 Northwind Health Company, LLC 30 TABLET in 1 BOTTLE, PLASTIC (51655-058-52) March 10, 2023
51655-110-26 51655-110 Northwind Health Company, LLC 90 TABLET in 1 BOTTLE, PLASTIC (51655-110-26) September 7, 2022
51655-110-52 51655-110 Northwind Health Company, LLC 30 TABLET in 1 BOTTLE, PLASTIC (51655-110-52) October 17, 2022
51655-341-26 51655-341 Northwind Health Company, LLC 90 TABLET in 1 BOTTLE, PLASTIC (51655-341-26) May 28, 2020
68071-3820-3 68071-3820 NuCare Pharmaceuticals, Inc. 30 TABLET in 1 BOTTLE (68071-3820-3) March 27, 2025
68071-3820-9 68071-3820 NuCare Pharmaceuticals, Inc. 90 TABLET in 1 BOTTLE (68071-3820-9) March 12, 2026
68071-1793-1 68071-1793 NuCare Pharmaceuticals,Inc. 100 TABLET in 1 BOTTLE (68071-1793-1) May 31, 2023
68071-3408-1 68071-3408 NuCare Pharmaceuticals,Inc. 100 TABLET in 1 BOTTLE (68071-3408-1) June 15, 2023
68071-3537-3 68071-3537 NuCare Pharmaceuticals,Inc. 30 TABLET in 1 BOTTLE (68071-3537-3) November 28, 2023
68682-710-01 68682-710 OCEANSIDE PHARMACEUTICALS 100 TABLET in 1 BOTTLE (68682-710-01) July 26, 1988
68682-710-10 68682-710 OCEANSIDE PHARMACEUTICALS 1000 TABLET in 1 BOTTLE (68682-710-10) July 26, 1988
68682-711-01 68682-711 OCEANSIDE PHARMACEUTICALS 100 TABLET in 1 BOTTLE (68682-711-01) December 24, 1985
68682-711-10 68682-711 OCEANSIDE PHARMACEUTICALS 1000 TABLET in 1 BOTTLE (68682-711-10) December 24, 1985
68682-712-01 68682-712 OCEANSIDE PHARMACEUTICALS 100 TABLET in 1 BOTTLE (68682-712-01) December 24, 1985
68682-712-10 68682-712 OCEANSIDE PHARMACEUTICALS 1000 TABLET in 1 BOTTLE (68682-712-10) December 24, 1985
68682-713-01 68682-713 OCEANSIDE PHARMACEUTICALS 100 TABLET in 1 BOTTLE (68682-713-01) December 24, 1985
68682-713-10 68682-713 OCEANSIDE PHARMACEUTICALS 1000 TABLET in 1 BOTTLE (68682-713-10) December 24, 1985
72789-318-90 72789-318 PD-Rx Pharmaceuticals, Inc. 90 TABLET in 1 BOTTLE, PLASTIC (72789-318-90) April 4, 2023
72789-329-90 72789-329 PD-Rx Pharmaceuticals, Inc. 90 TABLET in 1 BOTTLE, PLASTIC (72789-329-90) June 15, 2023
68788-8385-1 68788-8385 Preferred Pharmaceuicals Inc. 100 TABLET in 1 BOTTLE (68788-8385-1) March 1, 2023
68788-8385-3 68788-8385 Preferred Pharmaceuicals Inc. 30 TABLET in 1 BOTTLE (68788-8385-3) March 1, 2023
68788-8385-6 68788-8385 Preferred Pharmaceuicals Inc. 60 TABLET in 1 BOTTLE (68788-8385-6) March 1, 2023
68788-8385-9 68788-8385 Preferred Pharmaceuicals Inc. 90 TABLET in 1 BOTTLE (68788-8385-9) March 1, 2023
68788-4147-0 68788-4147 Preferred Pharmaceuticals Inc. 100 TABLET in 1 BOTTLE (68788-4147-0) July 10, 2026
68788-4147-3 68788-4147 Preferred Pharmaceuticals Inc. 30 TABLET in 1 BOTTLE (68788-4147-3) July 10, 2026
68788-4147-6 68788-4147 Preferred Pharmaceuticals Inc. 60 TABLET in 1 BOTTLE (68788-4147-6) July 10, 2026
68788-4147-9 68788-4147 Preferred Pharmaceuticals Inc. 90 TABLET in 1 BOTTLE (68788-4147-9) July 10, 2026
68788-4164-1 68788-4164 Preferred Pharmaceuticals Inc. 100 TABLET in 1 BOTTLE (68788-4164-1) July 23, 2026
68788-4164-3 68788-4164 Preferred Pharmaceuticals Inc. 30 TABLET in 1 BOTTLE (68788-4164-3) July 23, 2026
68788-4164-6 68788-4164 Preferred Pharmaceuticals Inc. 60 TABLET in 1 BOTTLE (68788-4164-6) July 23, 2026
68788-4164-9 68788-4164 Preferred Pharmaceuticals Inc. 90 TABLET in 1 BOTTLE (68788-4164-9) July 23, 2026
68788-8320-1 68788-8320 Preferred Pharmaceuticals Inc. 100 TABLET in 1 BOTTLE (68788-8320-1) January 24, 2023
68788-8320-3 68788-8320 Preferred Pharmaceuticals Inc. 30 TABLET in 1 BOTTLE (68788-8320-3) January 24, 2023
68788-8320-6 68788-8320 Preferred Pharmaceuticals Inc. 60 TABLET in 1 BOTTLE (68788-8320-6) January 24, 2023
68788-8320-9 68788-8320 Preferred Pharmaceuticals Inc. 90 TABLET in 1 BOTTLE (68788-8320-9) January 24, 2023
68788-8437-1 68788-8437 Preferred Pharmaceuticals Inc. 100 TABLET in 1 BOTTLE (68788-8437-1) April 28, 2023
68788-8437-3 68788-8437 Preferred Pharmaceuticals Inc. 30 TABLET in 1 BOTTLE (68788-8437-3) April 28, 2023
68788-8437-6 68788-8437 Preferred Pharmaceuticals Inc. 60 TABLET in 1 BOTTLE (68788-8437-6) April 28, 2023
68788-8437-9 68788-8437 Preferred Pharmaceuticals Inc. 90 TABLET in 1 BOTTLE (68788-8437-9) April 28, 2023
63187-977-30 63187-977 Proficient Rx LP 30 TABLET in 1 BOTTLE (63187-977-30) February 1, 2018
63187-977-60 63187-977 Proficient Rx LP 60 TABLET in 1 BOTTLE (63187-977-60) February 1, 2018
63187-977-90 63187-977 Proficient Rx LP 90 TABLET in 1 BOTTLE (63187-977-90) February 1, 2018
71205-075-30 71205-075 Proficient Rx LP 30 TABLET in 1 BOTTLE (71205-075-30) July 2, 2018
71205-075-60 71205-075 Proficient Rx LP 60 TABLET in 1 BOTTLE (71205-075-60) July 2, 2018
71205-075-90 71205-075 Proficient Rx LP 90 TABLET in 1 BOTTLE (71205-075-90) July 2, 2018
70518-3572-2 70518-3572 REMEDYREPACK INC. 30 TABLET in 1 BLISTER PACK (70518-3572-2) May 28, 2025
70518-4011-1 70518-4011 REMEDYREPACK INC. 90 TABLET in 1 BOTTLE, PLASTIC (70518-4011-1) September 13, 2025
70518-4011-2 70518-4011 REMEDYREPACK INC. 100 TABLET in 1 BOTTLE, PLASTIC (70518-4011-2) July 21, 2026
70518-4153-0 70518-4153 REMEDYREPACK INC. 90 TABLET in 1 BOTTLE, PLASTIC (70518-4153-0) August 1, 2024
70518-4153-1 70518-4153 REMEDYREPACK INC. 100 TABLET in 1 BOTTLE, PLASTIC (70518-4153-1) March 20, 2025
70518-4197-0 70518-4197 REMEDYREPACK INC. 90 TABLET in 1 BOTTLE, PLASTIC (70518-4197-0) October 1, 2024
70518-4197-1 70518-4197 REMEDYREPACK INC. 30 TABLET in 1 BLISTER PACK (70518-4197-1) May 3, 2025
70518-4197-2 70518-4197 REMEDYREPACK INC. 90 TABLET in 1 BOTTLE, PLASTIC (70518-4197-2) July 13, 2025
70518-4210-0 70518-4210 REMEDYREPACK INC. 90 TABLET in 1 BOTTLE, PLASTIC (70518-4210-0) October 10, 2024
70518-4210-1 70518-4210 REMEDYREPACK INC. 90 TABLET in 1 BOTTLE, PLASTIC (70518-4210-1) May 16, 2025
70518-4256-0 70518-4256 REMEDYREPACK INC. 30 TABLET in 1 BLISTER PACK (70518-4256-0) January 15, 2025
64980-685-01 64980-685 Rising Pharma Holdings, Inc. 100 TABLET in 1 BOTTLE (64980-685-01) February 24, 2025
64980-685-10 64980-685 Rising Pharma Holdings, Inc. 1000 TABLET in 1 BOTTLE (64980-685-10) February 24, 2025
64980-686-01 64980-686 Rising Pharma Holdings, Inc. 100 TABLET in 1 BOTTLE (64980-686-01) February 24, 2025
64980-686-10 64980-686 Rising Pharma Holdings, Inc. 1000 TABLET in 1 BOTTLE (64980-686-10) February 24, 2025
64980-687-01 64980-687 Rising Pharma Holdings, Inc. 100 TABLET in 1 BOTTLE (64980-687-01) February 24, 2025
64980-687-10 64980-687 Rising Pharma Holdings, Inc. 1000 TABLET in 1 BOTTLE (64980-687-10) February 24, 2025
64980-688-01 64980-688 Rising Pharma Holdings, Inc. 100 TABLET in 1 BOTTLE (64980-688-01) February 24, 2025
64980-688-10 64980-688 Rising Pharma Holdings, Inc. 1000 TABLET in 1 BOTTLE (64980-688-10) February 24, 2025
50228-228-01 50228-228 ScieGen Pharmaceuticals, Inc. 100 TABLET in 1 BOTTLE (50228-228-01) February 12, 2025
50228-228-10 50228-228 ScieGen Pharmaceuticals, Inc. 1000 TABLET in 1 BOTTLE (50228-228-10) February 12, 2025
50228-229-01 50228-229 ScieGen Pharmaceuticals, Inc. 100 TABLET in 1 BOTTLE (50228-229-01) February 12, 2025
50228-229-10 50228-229 ScieGen Pharmaceuticals, Inc. 1000 TABLET in 1 BOTTLE (50228-229-10) February 12, 2025
50228-230-01 50228-230 ScieGen Pharmaceuticals, Inc. 100 TABLET in 1 BOTTLE (50228-230-01) February 12, 2025
50228-230-10 50228-230 ScieGen Pharmaceuticals, Inc. 1000 TABLET in 1 BOTTLE (50228-230-10) February 12, 2025
50228-231-01 50228-231 ScieGen Pharmaceuticals, Inc. 100 TABLET in 1 BOTTLE (50228-231-01) February 12, 2025
50228-231-10 50228-231 ScieGen Pharmaceuticals, Inc. 1000 TABLET in 1 BOTTLE (50228-231-10) February 12, 2025
43547-545-03 43547-545 Solco Healthcare US, LLC 30 TABLET in 1 BOTTLE (43547-545-03) July 31, 2022
43547-545-09 43547-545 Solco Healthcare US, LLC 90 TABLET in 1 BOTTLE (43547-545-09) July 31, 2022
43547-545-10 43547-545 Solco Healthcare US, LLC 100 TABLET in 1 BOTTLE (43547-545-10) July 31, 2022
43547-545-11 43547-545 Solco Healthcare US, LLC 1000 TABLET in 1 BOTTLE (43547-545-11) July 31, 2022
43547-545-50 43547-545 Solco Healthcare US, LLC 500 TABLET in 1 BOTTLE (43547-545-50) July 31, 2022
43547-546-03 43547-546 Solco Healthcare US, LLC 30 TABLET in 1 BOTTLE (43547-546-03) July 31, 2022
43547-546-09 43547-546 Solco Healthcare US, LLC 90 TABLET in 1 BOTTLE (43547-546-09) July 31, 2022
43547-546-10 43547-546 Solco Healthcare US, LLC 100 TABLET in 1 BOTTLE (43547-546-10) July 31, 2022
43547-546-11 43547-546 Solco Healthcare US, LLC 1000 TABLET in 1 BOTTLE (43547-546-11) July 31, 2022
43547-546-50 43547-546 Solco Healthcare US, LLC 500 TABLET in 1 BOTTLE (43547-546-50) July 31, 2022
43547-547-03 43547-547 Solco Healthcare US, LLC 30 TABLET in 1 BOTTLE (43547-547-03) July 31, 2022
43547-547-09 43547-547 Solco Healthcare US, LLC 90 TABLET in 1 BOTTLE (43547-547-09) July 31, 2022
43547-547-10 43547-547 Solco Healthcare US, LLC 100 TABLET in 1 BOTTLE (43547-547-10) July 31, 2022
43547-547-11 43547-547 Solco Healthcare US, LLC 1000 TABLET in 1 BOTTLE (43547-547-11) July 31, 2022
43547-547-50 43547-547 Solco Healthcare US, LLC 500 TABLET in 1 BOTTLE (43547-547-50) July 31, 2022
43547-548-03 43547-548 Solco Healthcare US, LLC 30 TABLET in 1 BOTTLE (43547-548-03) July 31, 2022
43547-548-09 43547-548 Solco Healthcare US, LLC 90 TABLET in 1 BOTTLE (43547-548-09) July 31, 2022
43547-548-10 43547-548 Solco Healthcare US, LLC 100 TABLET in 1 BOTTLE (43547-548-10) July 31, 2022
43547-548-11 43547-548 Solco Healthcare US, LLC 1000 TABLET in 1 BOTTLE (43547-548-11) July 31, 2022
43547-548-50 43547-548 Solco Healthcare US, LLC 500 TABLET in 1 BOTTLE (43547-548-50) July 31, 2022
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51672-4037-1 51672-4037 Sun Pharmaceutical Industries, Inc. 100 TABLET in 1 BOTTLE (51672-4037-1) January 23, 2001
51672-4037-3 51672-4037 Sun Pharmaceutical Industries, Inc. 1000 TABLET in 1 BOTTLE (51672-4037-3) January 23, 2001
51672-4038-1 51672-4038 Sun Pharmaceutical Industries, Inc. 100 TABLET in 1 BOTTLE (51672-4038-1) January 23, 2001
51672-4038-3 51672-4038 Sun Pharmaceutical Industries, Inc. 1000 TABLET in 1 BOTTLE (51672-4038-3) January 23, 2001
51672-4040-1 51672-4040 Sun Pharmaceutical Industries, Inc. 100 TABLET in 1 BOTTLE (51672-4040-1) January 23, 2001
51672-4040-3 51672-4040 Sun Pharmaceutical Industries, Inc. 1000 TABLET in 1 BOTTLE (51672-4040-3) January 23, 2001
51672-4245-1 51672-4245 Sun Pharmaceutical Industries, Inc. 100 TABLET in 1 BOTTLE (51672-4245-1) July 17, 2023
51672-4245-3 51672-4245 Sun Pharmaceutical Industries, Inc. 1000 TABLET in 1 BOTTLE (51672-4245-3) July 17, 2023
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69292-542 69292-542 Amici Pharma, Inc — October 15, 2025
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0904-7309 0904-7309 Major Pharmaceuticals — August 28, 2025
0904-7310 0904-7310 Major Pharmaceuticals — August 28, 2025
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43547-546 43547-546 Solco Healthcare US, LLC — July 31, 2022
43547-547 43547-547 Solco Healthcare US, LLC — July 31, 2022
43547-548 43547-548 Solco Healthcare US, LLC — July 31, 2022
60760-575 60760-575 St. Mary's Medical Park Pharmacy — October 31, 2022
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51672-4038 51672-4038 Sun Pharmaceutical Industries, Inc. — January 23, 2001
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Sources for this page

Every dataset that contributed a fact to this page.
Dataset Agency Used for
NDC Directory FDA Identity, ingredients, strengths, forms, routes, labelers, packages
Drugs@FDA FDA Application, sponsor, submissions, review documents, marketing status
Orange Book FDA Therapeutic equivalence codes, reference drug flags, patents, exclusivity
Drug Labeling FDA / NLM Prescribing information reproduced above
FAERS FDA Adverse event report counts
Enforcement FDA Recall records

Generated September 25, 2026 · 13 sections on this page.