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CVS Pharmacy
Clotrimazole · Cream
Overview
Active ingredients
Source: NDC DirectoryForms, strengths and routes
Source: NDC DirectoryPharmacologic classes are listed in the class section below.
Pharmacologic class
Source: NDC Directory| Class | Type | Browse |
|---|---|---|
| Allergens [CS] | CS | 2 members — no class page |
| Allylamine Antifungal [EPC] | EPC | All 11 members |
| Allylamine [CS] | CS | All 11 members |
| Azole Antifungal [EPC] | EPC | All 44 members |
| Azoles [CS] | CS | All 44 members |
| Cell-mediated Immunity [PE] | PE | 2 members — no class page |
| Increased Histamine Release [PE] | PE | 2 members — no class page |
| Standardized Chemical Allergen [EPC] | EPC | 1 member — no class page |
Regulatory status
Source: Drugs@FDANDC Directory| Product | Trade name | Form | Strength | Ingredient | Status | TE | Flags |
|---|---|---|---|---|---|---|---|
| 021143-001 | TRIVAGIZOLE 3 | CREAM | CLOTRIMAZOLE | Over-the-counter | — |
Approval history
Source: Drugs@FDA| Type | No. | Action | Status | Date | Review |
|---|---|---|---|---|---|
| Supplement | 12 | Labeling | Approved | August 25, 2016 | Standard |
| Supplement | 11 | Manufacturing (CMC) | Approved | May 15, 2014 | Standard |
| Supplement | 5 | Manufacturing (CMC) | Approved | December 10, 2002 | Standard |
| Supplement | 4 | Manufacturing (CMC) | Approved | November 8, 2002 | Standard |
| Supplement | 3 | Manufacturing (CMC) | Approved | September 17, 2001 | Standard |
| Supplement | 2 | Manufacturing (CMC) | Approved | January 10, 2001 | Standard |
| Supplement | 1 | Manufacturing (CMC) | Approved | October 18, 2000 | Standard |
| Original application | 1 | Type 3 - New Dosage Form | Approved | April 12, 2000 | Standard |
Prescribing information
Source: openFDA Drug LabelingReproduced verbatim from the Structured Product Labeling submitted to the FDA (effective 20250925). This is the manufacturer's labelling text, not a summary and not advice.
Indications and Usage
openFDA Drug LabelingUses cures most athlete's foot (tinea pedis) cures most jock itch (tinea cruris) and ringworm (tinea corporis) relieves itching, burning, cracking and scaling which accompany these conditions
Purpose
openFDA Drug LabelingActive ingredients Purpose Clotrimazole USP 2% (100 mg in each applicatorful) Vaginal antifungal Clotrimazole USP 2% (external cream) Vaginal antifungal
Dosage and Administration
openFDA Drug LabelingDirections adults and children 12 years and over: use the tip of the cap to break the seal and open the tube wash the affected skin with soap and water and dry completely before applying for athlete's foot wear well-fitting, ventilated shoes. Change shoes and socks at least once daily. between the toes only: apply twice a day (morning and night) for 1 week or as directed by a doctor on the bottom or sides of the foot: apply twice a day (morning and night) for 2 weeks or as directed by a doctor for jock itch and ringworm: apply once a day (morning or night) for 1 week or as directed by a doctor wash hands after each use children under 12 years: ask a doctor image
Warnings
openFDA Drug LabelingWarnings For vaginal use only Do not use if you have never had a vaginal yeast infection diagnosed by a doctor Ask a doctor before use if you have vaginal itching and discomfort for the first time lower abdominal, back or shoulder pain, fever, chills, nausea, vomiting, or foul-smelling vaginal discharge. You may have a more serious condition. vaginal yeast infections often (such as once a month or 3 in 6 months). You could be pregnant or have a serious underlying medical cause for your symptoms, including diabetes or a weakened immune system. been exposed to the human immunodeficiency virus (HIV) that causes AIDS When using this product do not use tampons, douches, spermicides, or other vaginal products. Condoms and diaphragms may be damaged and fail to prevent pregnancy or sexually transmitted diseases (STDs). do not have vaginal intercourse mild increase in vaginal burning, itching or irritation may occur if you do not get complete relief ask a doctor before using another product Stop use and ask a doctor if symptoms do not get better in 3 days symptoms last more than 7 days you get a rash or hives, abdominal pain, fever, chills, nausea, vomiting, or a foul-smelling vaginal discharge If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.
Do Not Use
openFDA Drug LabelingDo not use on nails or scalp in or near the mouth or eyes for vaginal yeast infections
Ask a Doctor
openFDA Drug LabelingAsk a doctor before use if you have vaginal itching and discomfort for the first time lower abdominal, back or shoulder pain, fever, chills, nausea, vomiting, or foul-smelling vaginal discharge. You may have a more serious condition. vaginal yeast infections often (such as once a month or 3 in 6 months). You could be pregnant or have a serious underlying medical cause for your symptoms, including diabetes or a weakened immune system. been exposed to the human immunodeficiency virus (HIV) that causes AIDS
Stop Use
openFDA Drug LabelingStop use and ask a doctor if symptoms do not get better in 3 days symptoms last more than 7 days you get a rash or hives, abdominal pain, fever, chills, nausea, vomiting, or a foul-smelling vaginal discharge
Active Ingredient
openFDA Drug LabelingActive ingredients Purpose Clotrimazole USP 2% (100 mg in each applicatorful) Vaginal antifungal Clotrimazole USP 2% (external cream) Vaginal antifungal
Adverse event reports
Source: openFDA FAERSAttributed to this product's most-reported active ingredient: CLOTRIMAZOLE. Combination products with more than six active ingredients are not attributed, because a report count summed across a long ingredient list measures the list, not the medicine.
Packaging and NDCs
Source: NDC Directory| Package NDC | Product NDC | Labeler | Description | Marketing start |
|---|---|---|---|---|
| 59779-080-01 | 59779-080 | CVS Pharmacy | 1 TUBE in 1 CARTON (59779-080-01) / 15 g in 1 TUBE | July 2, 2007 |
| 59779-080-02 | 59779-080 | CVS Pharmacy | 1 TUBE in 1 CARTON (59779-080-02) / 30 g in 1 TUBE | July 2, 2007 |
| 59779-510-01 | 59779-510 | CVS Pharmacy | 1 TUBE in 1 CARTON (59779-510-01) / 15 g in 1 TUBE | January 10, 2013 |
| 69842-062-00 | 69842-062 | CVS Pharmacy | 1 TUBE, WITH APPLICATOR in 1 CARTON (69842-062-00) / 21 g in 1 TUBE, WITH APPLICATOR | August 6, 2019 |
| 69842-638-01 | 69842-638 | CVS Pharmacy | 1 TUBE in 1 CARTON (69842-638-01) / 42.5 g in 1 TUBE | May 1, 2005 |
| 59779-080 | 59779-080 | CVS Pharmacy | — | July 2, 2007 |
| 59779-510 | 59779-510 | CVS Pharmacy | — | January 10, 2013 |
| 69842-062 | 69842-062 | CVS Pharmacy | — | April 12, 2000 |
| 69842-638 | 69842-638 | CVS Pharmacy | — | May 1, 2005 |
Sources for this page
| Dataset | Agency | Used for |
|---|---|---|
| NDC Directory | FDA | Identity, ingredients, strengths, forms, routes, labelers, packages |
| Drugs@FDA | FDA | Application, sponsor, submissions, review documents, marketing status |
| Drug Labeling | FDA / NLM | Prescribing information reproduced above |
| FAERS | FDA | Adverse event report counts |
Generated September 25, 2026 · 10 sections on this page.